38544-16-0

Basic information

• Product Name: 2-(BENZYLOXY)-5-CHLOROBENZALDEHYDE
• Synonyms: 2-(BENZYLOXY)-5-CHLOROBENZALDEHYDE;AKOS B014137;CHEMBRDG-BB 3014137;ASISCHEM V02040;ART-CHEM-BB B014137;2-(benzyloxy)-5-chlorobenzaldehyde(SALTDATA: FREE);5-chloro-2-(phenylmethoxy)benzaldehyde
• CAS NO: 38544-16-0
• Molecular Formula: C₁₄H₁₁ClO₂
• Molecular Weight: 246.69
• Mol File: 38544-16-0.mol
• Article Data: 26

Chemical Properties

• Melting Point: 70-72 °C(Solv: hexane (110-54-3))
• Boiling Point: 384.9°C at 760 mmHg
• Flash Point: 160°C
• Appearance: /
• Density: 1.247g/cm³
• Vapor Pressure: 3.95E-06mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: 2-(BENZYLOXY)-5-CHLOROBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BENZYLOXY)-5-CHLOROBENZALDEHYDE(38544-16-0)
• EPA Substance Registry System: 2-(BENZYLOXY)-5-CHLOROBENZALDEHYDE(38544-16-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 38544-16-0(Hazardous Substances Data)

Usage

General Description

2-(Benzyloxy)-5-chlorobenzaldehyde is a chemical compound with the molecular formula C14H11ClO2. It is a benzaldehyde derivative with a benzyl ether functional group attached to the second carbon atom of the benzaldehyde ring. The presence of a chlorine atom on the benzaldehyde ring also gives this compound its characteristic properties. 2-(Benzyloxy)-5-chlorobenzaldehyde is commonly used in organic synthesis and as a building block for the preparation of various organic compounds. It is also used as an intermediate in the production of pharmaceuticals and agrochemicals. 2-(BENZYLOXY)-5-CHLOROBENZALDEHYDE has potential applications in the fields of biotechnology, pharmaceuticals, and materials science.

InChI:InChI=1/C14H11ClO2/c15-13-6-7-14(12(8-13)9-16)17-10-11-4-2-1-3-5-11/h1-9H,10H2

Upstream product

• 100-44-7 benzyl chloride 
• 635-93-8 5-chlorosalicyclaldehyde 
• 100-39-0 benzyl bromide 
• 90-02-8 salicylaldehyde 

Downstream Products

• 40276-13-9 2-Benzyloxy-5-chlor-β-nitrostyrol 
• 713115-29-8 {5-chloro-2-[(phenylmethyl)oxy]phenyl}methanol 
• 515160-03-9 3-(2-benzyloxy-5-chlorophenyl)-3-hydroxy-2-methylenepropanenitrile 
• 515160-07-3 methyl 3-(2-benzyloxy-3-chlorophenyl)-3-hydroxy-2-methylenepropanoate 
• 632627-71-5 1-[5-chloro-2-(benzyloxy)phenyl]-hexane-1,4-dione 
• 632625-42-4 1-[5-chloro-2-(benzyloxy)phenyl]-pentane-1,4-dione 
• 632621-54-6 3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-benzoic acid 
• 632625-43-5 3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-benzoic acid ethyl ester 
• 632627-72-6 3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-ethyl-pyrrol-1-yl}-benzoic acid ethyl ester 
• 902464-58-8 3-[5-(2-benzyloxy-5-chloro-phenyl)-3-bromo-2-methyl-pyrrol-1-yl]-benzoic acid 

Relevant articles and documents

Exploring intermolecular contacts in multi-substituted benzaldehyde derivatives: X-ray, Hirshfeld surface and lattice energy analyses

Crystal structures of six benzaldehyde derivatives (1-6) have been determined and their supramolecular networks were established by an X-ray crystallographic study. The study has shown that the compounds are linked by various intermolecular interactions s

3-Arylpropionylhydroxamic acid derivatives as Helicobacter pylori urease inhibitors: Synthesis, molecular docking and biological evaluation

Helicobacter pylori urease is involved in several physiologic responses such as stomach and duodenal ulcers, adenocarcinomas and stomach lymphomas. Thus, inhibition of urease is taken for a good chance to treat H. pylori-caused infections, we have therefore focused our efforts on seeking novel urease inhibitors. Here, a series of arylpropionylhydroxamic acids were synthesized and evaluated for urease inhibition. Out of these compounds, 3-(2-benzyloxy-5-chlorophenyl)-3-hydroxypropionylhydroxamic acid (d24) was the most active inhibitor with IC50of 0.15?±?0.05?μM, showing a mixed inhibition with both competitive and uncompetitive aspects. Non-linear fitting of kinetic data gives kinetics parameters of 0.13 and 0.12?μg·mL?1for Kiand Ki′, respectively. The plasma protein binding assays suggested that d24 exhibited moderate binding to human and rabbit plasma proteins.

Synthesis and evaluation of 3-hydroxy-3-phenylpropanoate ester-AZT conjugates as potential dual-action HIV-1 Integrase and Reverse Transcriptase inhibitors

Novel 3-hydroxy-3-phenylpropanoate ester-azidothymidine (AZT) conjugates have been prepared using Baylis-Hillman methodology, and their potential as dual-action HIV-1 Integrase and Reverse Transcriptase inhibitors has been explored using enzyme inhibition