386298-12-0

Basic information

• Product Name: N,N-diethyl-[3-cyano-4-(4-fluorophenyl)-4-oxo]butanamide
• Synonyms: N,N-diethyl-[3-cyano-4-(4-fluorophenyl)-4-oxo]butanamide
• CAS NO: 386298-12-0
• Molecular Weight: 276.311
• Mol File: 386298-12-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N,N-diethyl-[3-cyano-4-(4-fluorophenyl)-4-oxo]butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-[3-cyano-4-(4-fluorophenyl)-4-oxo]butanamide(386298-12-0)
• EPA Substance Registry System: N,N-diethyl-[3-cyano-4-(4-fluorophenyl)-4-oxo]butanamide(386298-12-0)

Safety Data

• Hazardous Substances Data: 386298-12-0(Hazardous Substances Data)

Upstream product

• 4640-67-9 3-(4-fluorophenyl)-3-oxopropionitrile 
• 2315-36-8 2-Chloro-N,N-diethylacetamide 

Downstream Products

• 386298-17-5 2-(3-amino-5-(4-fluorophenyl)-1H-pyrazol-4-yl)-N,N-diethylacetamide 

Relevant articles and documents

A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation

A suitable TSPO PET ligand may visualize and quantify neuroinflammation in a living brain. Herein we report a 18F-ligand, [18F]2 ([18F]FDPA), is radiolabeled in high yield and high specific activity based on our spirocyclic iodonium ylide (SCIDY) strategy. [18F]2 demonstrated saturable specific binding to TSPO, substantially elevated brain uptake, and slow washout of bound PET signal in the preclinical models of brain neuroinflammation (cerebral ischemia and Alzheimer's disease).