3870-07-3 Usage
Description
Triamcinolone acetonide 21-acetate is a glucocorticoid derivative of Triamcinolone Acetonide, which is a long-acting anti-inflammatory drug. It is a white solid and is widely used in the medical field, particularly in dermatology, due to its potent anti-inflammatory and immunosuppressive properties.
Uses
Used in Dermatology:
Triamcinolone acetonide 21-acetate is used as a long-acting glucocorticoid for the treatment of various skin conditions such as eczema and dermatitis. Its application in this field is due to its ability to reduce inflammation, suppress the immune system, and alleviate skin irritation.
Used in Respiratory Medicine:
As an antiasthmatic agent, Triamcinolone acetonide 21-acetate is used in inhalant form to manage asthma and other respiratory conditions. It helps to reduce inflammation in the airways, improving breathing and reducing the severity of asthma attacks.
Glucocorticoid
Triamcinolone acetonide acetate ，as a glucocorticoid drug, is white or almost white crystalline powder, which is odorless and bitter taste. It is slightly soluble in water, ethanol and acetone and soluble in chloroform. It is currently a long-acting glucocorticoid drug widely used in our dermatology clinical application, also known as Block technique, triamcinolone acetonide, Connor music cream and Conor-A. It belongs to adrenocortical hormones drugs and s from the triamcinolone. The effects of glucocorticoid triamcinolone acetonide acetate, similar to the role of triamcinolone, includes anti-inflammatory, anti-allergic, anti-itching and contracting capillaries. The role of its water and sodium retention is weak, while the anti-Inflammatory and anti-allergic effects are stronger and more durable than hydrocortisone (10 to 30 times) and prednisone. Its application in aerosol inhalation treatment of bronchial asthma is strong and lasting. The local curative effect is better than the triamcinolone. Oral is easy to absorb. Oral administration is 5mg and the bioavailability is about 23%. Its plasma concentration reaches the peak value of 105mg/ml after 1 hour, with a half-life of 2 hours. The intramuscular injection has a slow absorption process, and its effects begin within a few hours, reach to the maximum after 1 or 2 days and last about 2 or 3 weeks; the intradermal and intra-articular injection of this drug has slow-absorption and lasting-effects and the general effects of one injection can be maintained for 1 to 2 weeks or more. This drug binds with plasma albumin less, metabolizes into non-active metabolites in the liver, kidney and tissue and finally is excreted by the kidneys. Local injection can also have a lasting effect, as well as ointment topical.
Clinically, the triamcinolone acetonide is mainly used for the treatment of various skin diseases such as atopic dermatitis, contact dermatitis, seborrheic dermatitis, neurodermatitis, eczema, psoriasis, psoriasis, lichen planus and other skin diseases and skin pruritus, as well as many infectious diseases including bronchial asthma, rheumatoid arthritis, acute sprain, chronic low back pain, scapulohumeral periarthritis, tenosynovitis, eye inflammation, oral mucosal hyperemia, erosions, ulcers, granulomatous cheilitis and oral mucosa. It can also be used in the local injection of some small area damages like keloid, cystic acne, discoid lupus erythematosus and alopecia areata. Triamcinolone acetonide acetate nasal spray can be used for the prevention and treatment of perennial and seasonal allergic rhinitis and vasomotor rhinitis. Its intra-articular injection can eliminate inflammation and relieve the pain, swelling or stiffness felling.
Check Digit Verification of cas no
The CAS Registry Mumber 3870-07-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,8,7 and 0 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 3870-07:
(6*3)+(5*8)+(4*7)+(3*0)+(2*0)+(1*7)=93
93 % 10 = 3
So 3870-07-3 is a valid CAS Registry Number.
3870-07-3Relevant articles and documents
Triamcinolone acetonide acetate preparation method
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, (2018/03/24)
The invention provides a full-novel synthesizing route for preparing triamcinolone acetonide acetate. According to the full-novel synthetic route, utilized raw materials have lower cost and more easiness in obtaining. The synthetic route comprises the steps of hydroxylating reaction raw materials and protecting, then selectively oxidizing five-membered ring double bonds, removing a protecting group, then protecting oxidized di-hydroxyl, then epoxidizing six-membered ring double bonds, performing open-ring fluorination and esterfying hydroxyl to obtain a triamcinolone acetonide product. A reaction process has easiness in operation, yields of all the steps are higher, obtained products have higher purities, byproduct generation is effectively avoided, production cost is reduced, and industrial production is facilitated.
