387335-31-1

Basic information

• Product Name: 1H-2-Benzopyran-4-ol (9CI)
• Synonyms: 1H-2-Benzopyran-4-ol (9CI);1H-2-Benzopyran-4-ol;1H-isochroMen-4-ol
• CAS NO: 387335-31-1
• Molecular Formula: C9H8O2
• Molecular Weight: 148.15862
• Product Categories: ALCOHOL
• Mol File: 387335-31-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 296.2 °C at 760 mmHg
• Flash Point: 144.8 °C
• Appearance: /
• Density: 1.281 g/cm³
• Vapor Pressure: 0.000657mmHg at 25°C
• Refractive Index: 1.631
• CAS DataBase Reference: 1H-2-Benzopyran-4-ol (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-2-Benzopyran-4-ol (9CI)(387335-31-1)
• EPA Substance Registry System: 1H-2-Benzopyran-4-ol (9CI)(387335-31-1)

Safety Data

• Hazardous Substances Data: 387335-31-1(Hazardous Substances Data)

Usage

General Description

1H-2-Benzopyran-4-ol (9CI) is a chemical compound also known as coumarin, which is a fragrant organic chemical compound commonly found in plants such as tonka beans, cinnamon, and grass varieties. Coumarin is used in the production of pharmaceuticals, perfumes, and flavorings due to its sweet, vanilla-like scent. However, excessive consumption of coumarin has been linked to liver toxicity, and its use as a food additive is regulated in some countries. Overall, 1H-2-Benzopyran-4-ol (9CI) has both beneficial and potentially harmful effects, and its use is carefully monitored in various industries.

InChI:InChI=1/C9H8O2/c10-9-6-11-5-7-3-1-2-4-8(7)9/h1-4,6,10H,5H2

Relevant articles and documents

Keto - Enol/enolate equilibria in the isochroman-4-one system. Effect of a β-oxygen substituent

The enol of 1-tetralone was generated flash photolytically, and rates of its ketonization were measured in aqueous HClO4 and NaOH solutions as well as in CH3CO2H, H2PO4-, (CH2OH)3CNH3+, and NH4+ buffers. The enol of isochroman-4-one was also generated, by hydrolysis of its potassium salt and trimethylsilyl ether, and rates of its ketonization were measured in aqueous HClO4 and NaOH. Rates of enolization of the two ketones were measured as well. Combination of the enolization and ketonization data for isochroman-4-one gave the keto - enol equilibrium constant pKE = 5.26, the acidity constant of the enol ionizing as an oxygen acid pQaE = 10.14, and the acidity constant of the ketone ionizing as a carbon acid pQaK = 15.40. Comparison of these results with those for 1-tetralone shows that the β-oxygen substituent in isochroman-4-one raises all three of these constants: KE by 2 orders of magnitude, QaE by not quite 1 order of magnitude, and QaK by nearly 3 orders of magnitude. The β-oxygen substituent also retards the rate of hydronium-ion-catalyzed ketonization by more than 3 orders of magnitude. The origins of these substituent effects are discussed.