3878-67-9

Basic information

• Product Name: Benzenamine, N-(cyclohexylcarbonimidoyl)-
• Synonyms: N-cyclohexyl-N'-phenyl carbodiimide;N-phenyl,N′-cyclohexylcarbodiimide;N-phenyl-N′-cyclohexylcarbodiimide;N-[(cyclohexylimino)methylene]aniline;N-((cyclohexylimino)methylene)aniline;Cyclohexyl-phenyl-carbodiimide;N-phenyl-N'-(cyclohexyl)carbodiimide
• CAS NO: 3878-67-9
• Molecular Formula: C13H16N2
• Molecular Weight: 200.283
• Mol File: 3878-67-9.mol
• Article Data: 22

Chemical Properties

• Density: 1.03(20.0000℃)
• CAS DataBase Reference: Benzenamine, N-(cyclohexylcarbonimidoyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, N-(cyclohexylcarbonimidoyl)-(3878-67-9)
• EPA Substance Registry System: Benzenamine, N-(cyclohexylcarbonimidoyl)-(3878-67-9)

Safety Data

• Hazardous Substances Data: 3878-67-9(Hazardous Substances Data)

Upstream product

• 603-35-0 triphenylphosphine 
• 722-03-2 N-cyclohexyl-N'-phenylthiourea 
• 931-53-3 Cyclohexyl isocyanide 
• 62-53-3 aniline 
• 456-64-4 phenyl trifluoromethanesulfonamide 
• 538-75-0 dicyclohexyl-carbodiimide 
• 3173-53-3 Cyclohexyl isocyanate 
• 2325-27-1 N-phenyltriphenyliminophosphorane 
• 622-37-7 Phenyl azide 
• 103-71-9 phenyl isocyanate 
• 19573-22-9 cyclohexyl azide 
• 103-72-0 phenyl isothiocyanate 
• 108-91-8 cyclohexylamine 
• 25939-01-9 p-toluoyl chloride phenylhydrazone 

Downstream Products

• 1284224-16-3 N-cyclohexyl-6-methyl-1-phenyl-1H-2-aminobenzimidazole 
• 1284224-17-4 N-cyclohexyl-6-fluoro-1-phenyl-1H-2-aminobenzimidazole 
• 1284224-15-2 N-cyclohexyl-1-phenyl-1H-2-aminobenzimidazole 
• 1428967-48-9 C₂₈H₃₁F₆N₃O₄ 
• 1428966-96-4 C₂₈H₃₁F₆N₃O₄ 
• 4833-42-5 N-phenyl-N',N-dicyclohexylguanidine 

Relevant articles and documents

Reaction of N-Phenyltrifluoromethanesulfonamide with Carbodiimides

N-Phenyltrifluoromemanesulfonamide reacted with N,N′-dicyclohexylcarbodiimide in methylene chloride to give exchange products, N-cyclohexyltrifluoromethanesulfonamide and N-cyclohexyl-N′-phenylcarbodiimide. Reaction of the latter with trifluoromethanesulf

Copper(II)-Catalyzed Aerobic Oxidative Desulfitative 6π Electrocyclization: Efficient Synthesis of Diverse 4-Aminoquinolines

The C?C bond formation via C?S bond activation (disclosed in 2000) has received increasing attention. However, stoichiometric amounts of exogenous thiophilic reagents are generally required as thiolate scavengers. Herein, a new model for the synthesis of 4-aminoquinolines, the copper(II)-catalyzed aerobic oxidative desulfitative 6π cyclization of the readily available N-arylimino ketene N,S-acetals is described. The reaction can proceed efficiently under mild conditions without any exogeneous thiolate scavengers (due to the formation of disulfide as the by-product) to afford diverse 4-aminoquinolines, a privileged structure motif displaying antimalarial activity, with a wide range of functional groups at the C-2 to C-8 positions. (Figure presented.).

Ultrasonic-assisted synthesis of carbodiimides from N,N′-disubstituted thioureas and ureas

A facile and efficient sonochemical method for the preparation of carbodiimides from their corresponding thioureas or ureas was described. Using Ph3P–I2 combination in the presence of triethylamine, various diaryl, aryl–alkyl, as well as dialkyl substituted substrates could be converted into carbodiimides in good-to-excellent yields within short reaction times under mild conditions with simple experimental setup. Graphical abstract: [Figure not available: see fulltext.]