3883-64-5

Basic information

• Product Name: 7-aMinoisobenzofuran-1(3H)-one
• Synonyms: 7-aMinoisobenzofuran-1(3H)-one;7-AMINOZSOBENZOFURAN-1(3H)-ONE
• CAS NO: 3883-64-5
• Molecular Formula: C₈H₇NO₂
• Molecular Weight: 149.14668
• Mol File: 3883-64-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-aMinoisobenzofuran-1(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-aMinoisobenzofuran-1(3H)-one(3883-64-5)
• EPA Substance Registry System: 7-aMinoisobenzofuran-1(3H)-one(3883-64-5)

Safety Data

• Hazardous Substances Data: 3883-64-5(Hazardous Substances Data)

Usage

Description

7-aminobenzofuran-1(3H)-one, also known as 7AIB, is a heterocyclic compound with a molecular formula of C8H7NO2. It is a derivative of benzofuran and contains an amino group. This chemical is commonly used in organic synthesis and pharmaceutical research. 7AIB has been found to have potential anti-tumor and anti-inflammatory properties, making it a promising candidate for drug development. Additionally, its unique structure and reactivity make it a valuable building block for the synthesis of various biologically active compounds. Overall, 7-aminobenzofuran-1(3H)-one is a versatile compound with potential applications in medicinal chemistry and drug discovery.

Uses

Used in Pharmaceutical Research:
7-aminobenzofuran-1(3H)-one is used as a pharmaceutical candidate for its potential anti-tumor and anti-inflammatory properties. It is being explored for its ability to modulate various signaling pathways and exert inhibitory effects on tumor growth and progression.
Used in Organic Synthesis:
7-aminobenzofuran-1(3H)-one is used as a building block in the synthesis of various biologically active compounds. Its unique structure and reactivity make it a valuable component in the development of new drugs and therapeutic agents.
Used in Drug Development:
7-aminobenzofuran-1(3H)-one is used as a promising candidate for drug development due to its potential therapeutic applications. Researchers are investigating its efficacy in treating various diseases and conditions, particularly in the areas of oncology and inflammation.
Used in Medicinal Chemistry:
7-aminobenzofuran-1(3H)-one is used in medicinal chemistry for its potential to contribute to the discovery of new drugs and therapeutic agents. Its versatile chemical properties and potential for modification make it an attractive target for further research and development.

Upstream product

• 103260-68-0 7-acetamidophthalide 
• 42760-46-3 7-nitro-3H-isobenzofuran-1-one 
• 56-23-5 tetrachloromethane 
• 2518-24-3 3-aminophthalimide 
• 7732-18-5 water 
• 7758-99-8 copper(II) sulfate 
• 4389-50-8 2-amino-6-methylbenzoic acid 
• 632340-58-0 2-bromomethyl-6-amino-benzoic acid 
• 90407-20-8 2-bromo-3-(hydroxymethyl)-1-nitrobenzene 
• 6744-85-0 2-(methoxycarbonyl)-3-nitrobenzoic acid 
• 6296-53-3 3-acetylaminophthalic anhydride 
• 641-70-3 3-nitrophthalic acid anhydride 

Downstream Products

• 633337-83-4 7-benzoylamino-phthalide 
• 105694-44-8 7-bromoisobenzofuran-1-(3H)-one 
• 327626-87-9 7-(o-carboxyphenyl)aminophthalide 
• 327626-91-5 7-(o-formyl)phenylaminophthalide 
• 327626-90-4 7-(o-hydroxymethyl)phenylaminophthalide 

Relevant articles and documents

An improved method for the synthesis of γ-lactones using sodium bromate and sodium hydrogen sulfite

o-Alkylbenzenecarboxylic acids are treated with a sodium bromate and sodium hydrogen sulfite reagent under a two-phase system using ethyl acetate as solvent, under mild conditions to give the corresponding cyclized phthalides in moderate to satisfactory yield. Intermediately the α-brominated alkylbenzenecarboxylic acids are formed by the in situ generated hypobromous acid. These α-brominated acids undergo an intramolecular nucleophilic substitution reaction to afford the corresponding γ-lactones.

Synthesis, X-ray structure, electrochemical properties and cytotoxic effects of new arene ruthenium(II) complexes

A series of novel half-sandwich organoruthenium(II) complexes with the general formula [(η6-arene)Ru(L)Cl2] (where L = flavone, chromone or benzofuranone derivatives) have been synthesized. All the ligands in the reaction with [(η6-p-cymene)RuCl) 2(μ-Cl)2] form monodentate compounds, which were fully characterized by elemental analysis, MS, UV-Vis, IR and NMR spectroscopy. The molecular structure of one of the complexes [(η6-p-cymene)Ru(7- amino-3H-benzofuran-1-one-κ1-N)Cl2] was determined by X-ray crystallography. The redox properties of the complexes were monitored by cyclic voltammetry. The cytotoxicity of all obtained compounds has also been evaluated on several melanoma and leukemic cell lines.

Fast microwave promoted palladium-catalyzed synthesis of phthalides from bromobenzyl alcohols utilizing DMF and Mo(CO)6 as carbon monoxide sources

A fast method utilizing in situ generated CO for the synthesis of phthalides has been developed. DMF and Mo(CO)6 were applied as two alternative CO-sources in these microwave promoted carbonylation-lactone formation reactions. Mo(CO)6 was found to be the more generally applicable CO-source and provided phthalides as well as dihydroisocoumarin, dihydroisoindone, and phthalimide from the corresponding aryl bromide via an efficient CO insertion within a 1h reaction time.