38868-78-9Relevant articles and documents
Rapid, One-Step Synthesis of α-Ketoacetals via Electrophilic Etherification
Paris, Timothy J.,Schwartz, Chris,Sundall, Eric,Willand-Charnley, Rachel
, p. 14797 - 14811 (2021/10/20)
Herein, we report a rapid, one-step synthesis of α-ketoacetals via electrophilic etherification of α-alkoxy enolates and monoperoxyacetals. Methyl, primary, and secondary α-ketoacetals were obtained in 44-63% yields from tetrahydropyranyl substrates; usin
Solvent directed electrophilic iodination and phenylselenenylation of activated alkyl aryl ketones
Panunzi, Barbara,Rotiroti, Lucia,Tingoli, Marco
, p. 8753 - 8756 (2007/10/03)
A mixture of molecular iodine and phenyliodine(III) bis(trifluoroacetate) (BTI) in CH3CN (or CH3OH) iodinates the aromatic ring of some activated alkyl aryl ketones. A different outcome results if PhSeSePh is used instead of I2
Regiospecific synthesis of α-diones, α,α-dialkoxyketones and α-alkoxy-α-sulfenylated ketones
Tehrani,Boeykens,Tyvorskii,Kulinkovich,De Kimpe
, p. 6541 - 6548 (2007/10/03)
A convenient synthesis of α-diones and their monoprotected acetals, i.e. α-ketoacetals, was developed by mercury induced solvolysis of regiospecifically formed α-chloro-α-(alkylthio)ketones. Analogously, α-alkoxy-α-sulfenylated ketones were formed when reacting α-chloro-α-sulfenylated ketones with an alkaline alcoholic medium, α-Alkoxy-α-sulfenylated ketones themselves could be transformed into α-diones or ?-ketoacetals, which in turn were hydrolyzed under anhydrous conditions into the corresponding α-diones. (C) 2000 Elsevier Science Ltd.
