38901-30-3 Usage
Description
4-[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]-3-THIOSEMICARBAZIDE is a thiosemicarbazide derivative that features a phenyl ring substituted with a chlorine atom and a trifluoromethyl group, along with a thiosemicarbazide group. This chemical compound has garnered attention for its potential biological activities, such as antimicrobial and anticancer properties, and its utility in organic synthesis as a reagent or intermediate for preparing other compounds. Its unique structure and properties also make it a subject of interest for further research into applications in pharmacology and medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
4-[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]-3-THIOSEMICARBAZIDE is used as a potential active pharmaceutical ingredient for its antimicrobial and anticancer properties. Its ability to target and inhibit the growth of certain microbes and cancer cells makes it a promising candidate for the development of new drugs to combat these health challenges.
Used in Organic Synthesis:
In the field of organic synthesis, 4-[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]-3-THIOSEMICARBAZIDE serves as a reagent or intermediate. Its unique structure allows it to participate in various chemical reactions, facilitating the synthesis of a range of other compounds with diverse applications.
Used in Research and Development:
4-[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]-3-THIOSEMICARBAZIDE is utilized in research and development for its potential applications in pharmacology and medicinal chemistry. Its exploration can lead to a better understanding of its properties and mechanisms of action, which may contribute to the discovery of new therapeutic agents or synthetic methods.
Check Digit Verification of cas no
The CAS Registry Mumber 38901-30-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,9,0 and 1 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 38901-30:
(7*3)+(6*8)+(5*9)+(4*0)+(3*1)+(2*3)+(1*0)=123
123 % 10 = 3
So 38901-30-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H7ClF3N3S/c9-6-2-1-4(14-7(16)15-13)3-5(6)8(10,11)12/h1-3H,13H2,(H2,14,15,16)
38901-30-3Relevant articles and documents
Thiosemicarbazide, a fragment with promising indolamine-2,3-dioxygenase (IDO) inhibition properties
Serra, Silvia,Moineaux, Laurence,Vancraeynest, Christelle,Masereel, Bernard,Wouters, Johan,Pochet, Lionel,Frédérick, Rapha?l
, p. 96 - 105 (2014/06/10)
With the aim to explore the interest of the thiosemicarbazide scaffold for the inhibition of the indoleamine 2,3-dioxygenase (IDO), a promising therapeutic target for anticancer immunotherapy, a series of 32 phenylthiosemicarbazide derivatives was prepared and their IDO inhibition evaluated. Our study demonstrated that among these derivatives, compound 14 characterized with a 4-cyanophenyl group on the thiosemicarbazide was the more potent IDO inhibitor in this series being endowed with an IC50 of 1.2 μM. The SAR depicted showed that substitution in the 3- and 4-position relative to the phenylthiosemicarbazide are very promising whereas substitution in the 2-position always leads to less potent or inactive derivatives. In fact the study highlighted a novel interesting scaffold for IDO inhibition for further development.
