39028-27-8 Usage
Description
IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER, also known as SIA Crosslinker, is a non-cleavable, water-soluble crosslinker containing an NHS ester and an iodine group. The NHS ester is reactive toward amines, while the iodine reacts with thiol groups. It is a heterobifunctional protein crosslinking reagent with a spacer arm of 1.5 Angstroms. SIA Crosslinker is a white solid and is used for various applications in different industries.
Uses
Used in Pharmaceutical Industry:
IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER is used as a sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent for forming covalent bonds between proteins, which can be useful in the development of drugs and drug delivery systems.
Used in Chemical Synthesis:
IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER is used as a reagent for forming water-soluble carboxylate derivatives, which can be useful in various chemical synthesis processes.
Used in Research and Development:
IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER is used as a research tool for studying protein interactions, protein structure, and protein function due to its ability to form covalent bonds between proteins and other molecules.
Used in Biochemical Analysis:
IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER is used as a crosslinking agent in biochemical analysis to study the structure and function of proteins and other biomolecules.
Biological Activity
SIA Crosslinker is a non-cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs).
Check Digit Verification of cas no
The CAS Registry Mumber 39028-27-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,0,2 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 39028-27:
(7*3)+(6*9)+(5*0)+(4*2)+(3*8)+(2*2)+(1*7)=118
118 % 10 = 8
So 39028-27-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H6INO4/c7-3-6(11)12-8-4(9)1-2-5(8)10/h1-3H2
39028-27-8Relevant articles and documents
DNA-TEMPLATED MACROCYCLE LIBRARY
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Paragraph 00232; 00234, (2019/09/18)
The present invention provides nucleic acid templates (e.g., including orthogonal codon sets (e.g., codons from orthogonal codon sets depicted in Tables 5 or 7)) for DNA-templated methods of synthesizing, selecting, and amplifying compounds (e.g., polymers and/or small molecules) described herein. Also provided are novel macrocyclic compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, libraries, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing a disease (e.g., a disease associated with aberrant enzyme activity (e.g., aberrant protease and/or kinase activity (e.g., aberrant IDE activity)), impaired insulin signaling, or insulin resistance in a subject (e.g., a subject having diabetes). Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit aberrant protease activity (e.g., aberrant IDE activity).
HAPTENS AND IMMUNOREACTIVE AGENTS AND USE THEREOF FOR PRODUCING FAMILY ANTIBODIES AND IMMUNOASSAYS FOR QUINOLONES
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Page/Page column 0092; 0111-0112; 0114, (2013/10/22)
The invention relates to haptens, immunogens and secondary immunoreactive agents, to the use thereof for producing wide-spectrum antibodies against quinolone-type antibiotics, to the application thereof to immunochemical analysis techniques, and to a kit enabling the detection of said antibiotics in biological samples from food products of animal origin.
Affinity labeling of the pyridoxal phosphate binding site of the β2 subunit of Escherichia coli tryptophan synthetase
Higgins,Wilson Miles
, p. 4648 - 4652,4649, 4650 (2007/10/08)
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