391248-13-8 Usage
Description
R-4-AMINOMETHYL-THIAZOLIDINE-3-CARBOXYLIC ACID TERT-BUTYL ESTER is a chemical compound that serves as a crucial reactant in the synthesis of various pharmaceutical agents. It is characterized by its unique molecular structure, which allows it to participate in specific chemical reactions to produce desired compounds.
Uses
Used in Pharmaceutical Industry:
R-4-AMINOMETHYL-THIAZOLIDINE-3-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a reactant for the preparation of (thienopyridine)carboxamides, which are checkpoint 1 kinase (CHK1) inhibitors. These inhibitors play a significant role in the development of cancer therapeutics, as they help regulate cell cycle progression and DNA damage response, thus preventing the uncontrolled growth of cancer cells.
As a reactant in the synthesis of CHK1 inhibitors, R-4-AMINOMETHYL-THIAZOLIDINE-3-CARBOXYLIC ACID TERT-BUTYL ESTER contributes to the advancement of cancer treatment options and the development of more effective drugs to combat this deadly disease.
Check Digit Verification of cas no
The CAS Registry Mumber 391248-13-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,9,1,2,4 and 8 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 391248-13:
(8*3)+(7*9)+(6*1)+(5*2)+(4*4)+(3*8)+(2*1)+(1*3)=148
148 % 10 = 8
So 391248-13-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H18N2O2S/c1-9(2,3)13-8(12)11-6-14-5-7(11)4-10/h7H,4-6,10H2,1-3H3/t7-/m1/s1
391248-13-8Relevant articles and documents
Asymmetric Michael reaction promoted by chiral thiazolidine-thiourea catalyst
da Silva, Tiago Lima,Rambo, Raoni Scheibler,Jacoby, Caroline Gross,Schneider, Paulo Henrique
, (2019/12/27)
In this work, we report the synthesis and characterization of three new thiazolidine- and thiourea-based chiral organocatalysts. These compounds were successfully applied in asymmetric Michael addition reactions between different ketones and nitrostyrenes leading to products in up to 85% yield, >96:4 r.d. and 97% e.e. Computational studies were used to better visualize the proposed transition state and explain the observed stereoselectivities. One of the new catalysts was also successfully applied in an aldol addition between cyclohexanone an p-nitrobenzaldehyde leading to product in 80% yield, >96:4 d.r. and 80% e.e.
