3913-23-3

Basic information

• Product Name: 2-METHOXY-5-NITROBENZYL BROMIDE
• Synonyms: 2-(bromomethyl)-1-methoxy-4-nitro-benzen;2-(bromomethyl)-4-nitro-anisol;alpha-bromo-2-methoxy-6-nitro-toluen;koshlandreagentno.2;2-BROMOMETHYL-4-NITROANISOLE;2-METHOXY-5-NITROBENZYL BROMIDE;KOSHLAND II;KOSHLAND'S REAGENT II
• CAS NO: 3913-23-3
• Molecular Formula: C₈H₈BrNO₃
• Molecular Weight: 246.06
• EINECS: 223-471-6
• Product Categories: Building Blocks;Chemical Synthesis;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
• Mol File: 3913-23-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 76-78 °C(lit.)
• Boiling Point: 348.7 °C at 760 mmHg
• Flash Point: 164.7 °C
• Appearance: UN 3261
• Density: 1.589±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 9.94E-05mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-METHOXY-5-NITROBENZYL BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-5-NITROBENZYL BROMIDE(3913-23-3)
• EPA Substance Registry System: 2-METHOXY-5-NITROBENZYL BROMIDE(3913-23-3)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• RTECS: XS7966500
• F: 19-21
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 3913-23-3(Hazardous Substances Data)

Usage

Description

2-Methoxy-5-nitrobenzyl bromide is an organic compound that serves as a potential mechanism-based inactivator of enzymes involved in O-dealkylations. It is characterized by its ability to modify tryptophan residues and is utilized in various applications across different industries.

Uses

Used in Pharmaceutical Industry:
2-Methoxy-5-nitrobenzyl bromide is used as a modifying agent for enhancing the activity of tryptophan residues in mouse interferon. This modification improves the effectiveness of the interferon, which plays a crucial role in the immune response against various diseases and conditions.
Used in Chemical Synthesis:
2-Methoxy-5-nitrobenzyl bromide is used as a reagent for sulfhydryl modification, which is an essential process in the synthesis of certain chemicals and compounds. Its ability to modify sulfhydryl groups makes it a valuable tool in the development of new chemical entities and pharmaceuticals.

Biochem/physiol Actions

2-Methoxy-5-nitrobenzyl bromide inactivates cytochrome P-450 in male rat liver microsomes.

InChI:InChI=1/C8H8BrNO3/c1-13-8-3-2-7(10(11)12)4-6(8)5-9/h2-4H,5H2,1H3

Upstream product

• 5804-49-9 2-methoxy-5-nitrophenylmethanol 
• 50-00-0 formaldehyd 
• 100-17-4 para-methoxynitrobenzene 
• 10035-10-6 hydrogen bromide 
• 39224-61-8 2-hydroxy-5-nitrobenzyl alcohol 
• 7383-11-1 2-aminomethyl-4-nitro-phenol 
• 25016-02-8 2-methoxy-5-nitrobenzaldehyde 

Downstream Products

• 143543-78-6 2-(2-Methoxy-5-nitrobenzylamino)-2-thiazoline 
• 50741-92-9 2-methyl-4-nitroanisole 
• 340255-37-0 2-Methoxy-5-nitrobenzyl (4-(2-hydroxyethoxy)-5-methoxy-2-{[(phenylacetyl)amino]methyl}phenyl)acetate 

Relevant articles and documents

THERAPEUTIC COMPOUNDS

The invention provides compounds of formula (I): wherein, A, C, D, X, and Y have any of the values defined in the specification, and salts thereof. The compounds are SIRT2 inhibitors and are useful for treating SIRT2 associated conditions.

COMPOUNDS THAT MODULATE EGFR ACTIVITY AND METHODS FOR TREATING OR PREVENTING CONDITIONS THEREWITH

Provided are compounds and methods for treating or preventing kinase-mediated disorders therewith.

COMPOUNDS

This invention relates to novel carboxylic acid indole compounds and compositions for use in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).