39145-52-3

Basic information

• Product Name: AC-HIS-OH H2O
• Synonyms: N-ALPHA-ACETYL-L-HISTIDINE H2O;N-ALPHA-ACETYL-L-HISTIDINE HYDRATE;N-ALPHA-ACETYL-L-HISTIDINE MONOHYDRATE;N-ACETYL-L-HISTIDINE HYDRATE;N-ACETYL-L-HISTIDINE MONOHYDRATE;ACETYL-L-HISTIDINE MONOHYDRATE;ACETYL-L-HISTIDINE H2O;AC-HIS-OH H2O
• CAS NO: 39145-52-3
• Molecular Formula: C8H13N3O4
• Molecular Weight: 215.21
• EINECS: 219-678-6
• Product Categories: Amino Acids and Derivatives;Ac-Amino Acids;Amino Acids;Amino Acids (N-Protected);Biochemistry;Amino Acid Derivatives
• Mol File: 39145-52-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 163 °C
• Boiling Point: 620.2 °C at 760 mmHg
• Flash Point: 328.9 °C
• Appearance: White/Powder
• Vapor Pressure: 8.02E-21mmHg at 25°C
• Refractive Index: 46.5 ° (C=1, H2O)
• Storage Temp.: Store at 0-5°C
• Solubility: DMSO (Slightly), Methanol (Sparingly, Heated), Water (Sparingly, Heated, Sonicat
• Water Solubility: Soluble in water.
• Stability: Stable. Incompatible with strong oxidizing agents.
• CAS DataBase Reference: AC-HIS-OH H2O(CAS DataBase Reference)
• NIST Chemistry Reference: AC-HIS-OH H2O(39145-52-3)
• EPA Substance Registry System: AC-HIS-OH H2O(39145-52-3)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-28
• Hazardous Substances Data: 39145-52-3(Hazardous Substances Data)

Usage

Description

AC-HIS-OH H2O, also known as N-acetylhistidine, is a novel osmolyte found in the lens of Atlantic salmon. It is a white crystalline powder with unique chemical properties that make it a valuable compound in various applications.

Uses

Used in Pharmaceutical Industry:
AC-HIS-OH H2O is used as a pharmaceutical compound for its potential role in the synthesis of histidine N-acetyltransferase, which is encoded by the ectotherm homologue of human predicted gene NAT16. This enzyme is responsible for the synthesis of N-acetylhistidine, making it a crucial component in the development of new drugs and therapies.
Used in Research and Development:
AC-HIS-OH H2O is used as a research compound for studying the properties and potential applications of osmolytes in various biological systems. Its unique chemical properties and role in the lens of Atlantic salmon make it an interesting subject for further investigation and potential development of new technologies or treatments.
Used in Chemical Synthesis:
AC-HIS-OH H2O is used as a chemical intermediate in the synthesis of various compounds, taking advantage of its unique properties as a white crystalline powder. This allows for the creation of new materials and products with potential applications in various industries.

Purification Methods

Crystallise it from water, then 4:1 acetone/water. [Marshall et al. J Am Chem Soc 78 4636 1956, Bergmann & Zervas Biochem Z 203 280 1928, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1990 1961, Beilstein 25 IV 4359.]

InChI:InChI=1/C8H11N3O3.H2O/c1-5(12)11-7(8(13)14)2-6-3-9-4-10-6;/h3-4,7H,2H2,1H3,(H,9,10)(H,11,12)(H,13,14);1H2