39200-98-1Relevant articles and documents
N,N′-Disubstituted Barbituric Acid: A Versatile and Modular Multifunctional Platform for Obtaining β-C-Glycoconjugates from Unprotected Carbohydrates in Water
Portier, Fran?ois,Solier, Justine,Halila, Sami
, p. 6158 - 6162 (2019)
Direct access to non-hydrolyzable glycoconjugates is highly mandatory for stabilizing their intrinsic biological or physical-chemistry properties in the surrounding environment. Here, a simple and versatile approach for the preparation of multifunctional clickable β-C-glycoconjugates has been developed. Readily accessible N,N′-disubstituted barbituric acids have been synthesized and ligated in water to the reducing end of unprotected carbohydrates via Knoevenagel condensation. Additionally, divalent glycoclusters have been built from bis-urea backbones and showed ability to interact with a model lectin, the peanut agglutinin. This concept can be readily adapted for the preparation of other C-glycoconjugates applicable in diverse area of glycosciences.
Method for photocatalytic synthesis of substituted urea compound
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Paragraph 0049-0050; 0057, (2021/06/09)
The invention relates to the technical field of organic synthesis, in particular to a method for photocatalytic synthesis of a substituted urea compound. The method specifically comprises the following steps: mixing tetrahalomethane and a solvent, then adding an amine compound and a catalyst in sequence, stirring and reacting under an oxygen-containing atmosphere and an illumination condition, and then separating and purifying to obtain the substituted urea compound, according to the synthesis method, the raw materials are wide in source, by-products produced after the reaction are halogen simple substances and high in additional value, on one hand, phosgene, triphosgene and the like which are high in toxicity are prevented from being adopted as raw materials, on the other hand, generation of a large amount of waste is avoided, the catalyst can be recycled, the influence of the preparation process on the environment is reduced, and the atom utilization rate of the reaction is improved.
Concise and Additive-Free Click Reactions between Amines and CF3SO3CF3
Song, Hai-Xia,Han, Zhou-Zhou,Zhang, Cheng-Pan
supporting information, p. 10907 - 10912 (2019/08/02)
Trifluoromethyl trifluoromethanesulfonate has proved to be an excellent reservoir of difluorophosgene and a promising click ligation for amines in the preparation of urea derivatives, heterocycles, and carbamoyl fluorides under metal- and additive-free conditions. The reactions are rapid, efficient, selective, and versatile, and can be performed in benign solvents, giving products in excellent yields with minimal efforts for purification. The characteristics of the reactions meet the requirements of a click reaction. The use of trifluoromethyl trifluoromethanesulfonate as a click reagent is advantageous over other “CO” sources (e.g., TsOCF3, PhCO2CF3, CsOCF3, AgOCF3, and triphosgene) because this reagent is readily accessible; easy to scale up; and highly reactive, even under metal- and additive-free conditions. It is anticipated that CF3SO3CF3 will be increasingly as important as SO2F2 as a click agent in future drug design and development.
