39208-61-2

Basic information

• Product Name: N-(3-methylphenyl)-1,3-benzoxazol-2-amine
• Synonyms: N-(3-methylphenyl)-1,3-benzoxazol-2-amine
• CAS NO: 39208-61-2
• Molecular Weight: 224.262
• Mol File: 39208-61-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(3-methylphenyl)-1,3-benzoxazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-methylphenyl)-1,3-benzoxazol-2-amine(39208-61-2)
• EPA Substance Registry System: N-(3-methylphenyl)-1,3-benzoxazol-2-amine(39208-61-2)

Safety Data

• Hazardous Substances Data: 39208-61-2(Hazardous Substances Data)

Upstream product

• 95-55-6 2-amino-phenol 
• 621-30-7 3-methylphenyl isothiocyanate 
• 32428-61-8 2-chloro-N-(3-methylphenyl)acetamide 
• 2382-96-9 2-sulfanyl-1,3-benzoxazole 
• 620-51-9 N,N'-di(3-methylphenyl)thiourea 
• 729550-47-4 S-methyl-N,N'-di-m-tolyl-isothiourea 
• 2382-96-9 benzo[d]oxazole-2-(3H)-thione 
• 108-44-1 1-amino-3-methylbenzene 

Relevant articles and documents

Electrochemical NaI/NaCl-mediated one-pot synthesis of 2-aminobenzoxazoles in aqueous mediaviatandem addition-cyclization

An electrochemical synthesis of 2-aminobenzoxazoles from 2-aminophenols and isothiocyanates was successfully developed in a one-pot fashion. Using inexpensive and widely available NaI and NaCl co-operatively in catalytic amounts, our electrosynthesis approach provided various 2-aminobenzoxazole products in moderate to high yields in an open-flask type undivided cell without using any external supporting electrolyte and base. The protocol can be applied to the synthesis of 2-aminobenzothiazoles from the corresponding 2-thiophenols in moderate yields. This protocol has many benefits. It is metal-free and highly scalable and uses inexpensive mediators and EtOH/water as an environmentally friendly solvent under mild conditions.

A Cu2O/TBAB-promoted approach to synthesize heteroaromatic 2-Amines: Via one-pot cyclization of aryl isothiocyanates with ortho-substituted amines in water

An efficient approach to synthesize heteroaromatic 2-Amines from one-pot desulfurization/dehydrogenative cyclization of aryl isothiocyanates with ortho-substituted amines in water was developed. This approach tolerated a wide range of functional groups on

Synthesis, biological evaluation and molecular docking study of N-arylbenzo[d]oxazol-2-amines as potential α-glucosidase inhibitors

A novel series of N-arylbenzo[d]oxazol-2-amines (4a–4m) were synthesized and evaluated for their α-glucosidase inhibitory activity. Compounds 4f–4i, 4k and 4m displayed potent inhibitory activity against α-glucosidase with IC50values in the range of 32.49?±?0.17–120.24?±?0.51?μM as compared to the standard drug acarbose. Among all tested compounds, compound 4g having 4-phenoxy substitution at the phenyl ring was found to be the most active inhibitor of α-glucosidase with an IC50value of 32.49?±?0.17?μM. Analysis of the kinetics of enzyme inhibition indicated that compound 4g is a noncompetitive inhibitor of α-glucosidase with a Kivalue of 31.33?μM. Binding interaction of compound 4g with α-glucosidase was explored by molecular docking simulation.