39228-29-0

Basic information

• Product Name: METHYL 2-NITROCINNAMATE
• Synonyms: METHYL 2-NITROCINNAMATE;(E)-Methyl 3-(2-Nitrophenyl)Acrylate
• CAS NO: 39228-29-0
• Molecular Formula: C₁₀H₉NO₄
• Molecular Weight: 207.18276
• Product Categories: Aromatic Cinnamic Acids, Esters and Derivatives
• Mol File: 39228-29-0.mol
• Article Data: 92

Chemical Properties

• Melting Point: 73°C
• Boiling Point: 346.2°C (rough estimate)
• Appearance: /
• Density: 1.3377 (rough estimate)
• Refractive Index: 1.5310 (estimate)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL 2-NITROCINNAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-NITROCINNAMATE(39228-29-0)
• EPA Substance Registry System: METHYL 2-NITROCINNAMATE(39228-29-0)

Safety Data

• Hazardous Substances Data: 39228-29-0(Hazardous Substances Data)

Usage

General Description

Methyl 2-nitrocinnamate is a chemical compound with the molecular formula C11H9NO4. It is commonly used in the synthesis of pharmaceuticals, agrochemicals, and organic intermediates. METHYL 2-NITROCINNAMATE is known for its antimicrobial and anti-inflammatory properties, making it a valuable ingredient in the production of various medicinal products. Methyl 2-nitrocinnamate is also used in the manufacturing of fragrances and flavorings, as it contributes to the pleasant aroma and taste of many consumer products. Additionally, it is utilized as a UV absorber in sunscreen formulations and as a colorant in cosmetic and hair dye products. Overall, methyl 2-nitrocinnamate plays a crucial role in the pharmaceutical, agricultural, and consumer goods industries due to its diverse applications and beneficial properties.

Upstream product

• 103-26-4 methyl cinnamate 
• 67-56-1 methanol 
• 612-41-9 2-nitrocinnamic acid 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 552-89-6 2-nitro-benzaldehyde 
• 103-26-4 Methyl cinnamate 
• 110-89-4 piperidine 
• 105-45-3 acetoacetic acid methyl ester 
• 612-41-9 2-nitrocinnamic acid 
• 96-32-2 bromoacetic acid methyl ester 
• 365-33-3 2-nitrobenzenediazonium tetrafluoroborate 
• 292638-85-8 acrylic acid methyl ester 
• 609-73-4 o-nitroiodobenzene 
• 577-19-5 2-nitrophenyl bromide 

Downstream Products

• 2001-33-4 o-nitrocinnamamide 
• 88939-75-7 methyl (2E)-3-(2-aminophenyl)propenoate 
• 4169-27-1 2-azabicyclo-[4.4.0]-decane-3-one 
• 88939-75-7 methyl β-(o-aminophenyl)acrylate 
• 612-41-9 2-nitrocinnamic acid 
• 109334-59-0 2-(3-Chloro-phenyl)-4-(2-nitro-phenyl)-5-phenyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 109334-56-7 1-(3-Chloro-phenyl)-5-(2-nitro-phenyl)-3-phenyl-1H-pyrazole-4-carboxylic acid methyl ester 
• 109334-60-3 2-(3-Bromo-phenyl)-4-(2-nitro-phenyl)-5-phenyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 109334-57-8 1-(3-Bromo-phenyl)-5-(2-nitro-phenyl)-3-phenyl-1H-pyrazole-4-carboxylic acid methyl ester 
• 1202-04-6 indole-2-carboxylic acid methyl ester 
• 1504-65-0 2-nitrocinnamyl alcohol 
• 109334-55-6 5-(2-Nitro-phenyl)-1,3-diphenyl-1H-pyrazole-4-carboxylic acid methyl ester 
• 109334-58-9 4-(2-Nitro-phenyl)-2,5-diphenyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 30009-04-2 trans-2-nitrocinnamohydroxamic acid 

Relevant articles and documents

Photoinduced Regioselective Olefination of Arenes at Proximal and Distal Sites

The Fujiwara-Moritani reaction has had a profound contribution in the emergence of contemporary C-H activation protocols. Despite the applicability of the traditional approach in different fields, the associated reactivity and regioselectivity issues had

A useful method for the conversion of olefins to nitro olefins

Triflyl nitrate is easily generated from tetra-n-butylammonium nitrate in CH2Cl2 solution and serves as an effective nitrating agent for a wide range of unsaturated substrates to form nitro olefins.

Synthesis of 2-(N-cyclicamino)quinoline combined with methyl (E)-3-(2/3/4-aminophenyl)acrylates as potential antiparasitic agents

A rationally designed series of 2-(N-cyclicamino)quinolines coupled with methyl (E)-3-(2/3/4-aminophenyl)acrylates was synthesized and subjected to in vitro screening bioassays for potential antiplasmodial and antitrypanosomal activities against a chloroquine-sensitive (3D7) strain of Plasmodium falciparum and nagana Trypanosoma brucei brucei 427, respectively. Substituent effects on activity were evaluated; meta-acrylate 24 and the ortho-acrylate 29 exhibited the highest antiplasmodial (IC50 = 1.4 μM) and antitrypanosomal (IC50 = 10.4 μM) activities, respectively. The activity against HeLa cells showed that the synthesized analogs are not cytotoxic at the maximum tested concentration. The ADME (absorption, distribution, metabolism, and excretion) drug-like properties of the synthesized compounds were predicted through the SwissADME software.