393-09-9 Usage
Chemical Properties
clear yellow liquid after melting
Uses
Different sources of media describe the Uses of 393-09-9 differently. You can refer to the following data:
1. 5-Fluoro-2-nitrobenzotrifluoride is a tri-substitiuted benzene derivative used in the preparation of androgen receptor modulators and other pharmaceutical compounds.
2. 5-Fluoro-2-nitrobenzotrifluoride may be used as monomer in the synthesis of hyperbranched poly(aryl ether). Also used in the preparation of androgen receptor modulators and other pharmaceutical compounds.
3. 5-Fluoro-2-nitrobenzotrifluoride may be used as monomer in the synthesis of hyperbranched poly(aryl ether).
General Description
5-Fluoro-2-nitrobenzotrifluoride is formed by the nitration of m-fluorobenzotrifluoride.
Check Digit Verification of cas no
The CAS Registry Mumber 393-09-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,9 and 3 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 393-09:
(5*3)+(4*9)+(3*3)+(2*0)+(1*9)=69
69 % 10 = 9
So 393-09-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H3F4NO2/c8-4-1-2-6(12(13)14)5(3-4)7(9,10)11/h1-3H
393-09-9Relevant articles and documents
Development of nonsteroidal antiandrogens: 4-Nitro-3-trifluoro-methyldiphenylamines
Humm,Schneider
, p. 83 - 87 (2007/10/02)
For the development of new nonsteroidal antiandrogens a series of 4-nitro-3-trifluoromethyldiphenylamines was synthesized and compounds were tested for their affinities to steroid hormone receptors and for antiandrogenic activities. These compounds were synthesized by reacting 4-nitro-3-trifluoromethylphenylsulfocyanamide-sodium (4) with the corresponding aromatic amines to give the N-(4-nitro-3-trifluoromethylphenylsulfonyl)-N'-phenylguanidines. The crude products were then converted to the desired diphenylamines by Smiles rearrangement and hydrolysis. 2-Hydroxy-4'-nitro-3'-trifluoromethyldiphenylamine (13), which shows a relative binding affinity (RBA) to the androgen receptor (AR) of 6.5% of that of testosterone, exerts a higher affinity than hydroxyflutamide (RBA = 4.5). Shift of the hydroxy-function to position 3 or 4 as well as N-methylation caused a decrease in AR-affinity. Compounds exerting AR-affinity were tested for antiandrogenic activity. Compound 13 showed the best antiandrogenic effect, though less than the well-known antiandrogen flutamide.