393-15-7

Basic information

• Product Name: 5-AMINO-2-METHOXYBENZOTRIFLUORIDE
• Synonyms: 3-AMINO-6-METHOXYBENZOTRIFLUORIDE;3-TRIFLUOROMETHYL-P-ANISIDINE;5-AMINO-2-METHOXYBENZOTRIFLUORIDE;4-METHOXY-3-(TRIFLUOROMETHYL)ANILINE;TIMTEC-BB SBB002596;5-amino-2-methoxybenzotrifluoride,97%;3-Amino-6-methoxybenzotriflyoride;3-Amino-6-methoxybenzotrifloride
• CAS NO: 393-15-7
• Molecular Formula: C₈H₈F₃NO
• Molecular Weight: 191.15
• EINECS: -0
• Mol File: 393-15-7.mol
• Article Data: 13

Chemical Properties

• Melting Point: 28 °C
• Boiling Point: 112 °C
• Flash Point: 112°C/18mm
• Appearance: Solid
• Density: 1.28 g/cm³
• Vapor Pressure: 0.0226mmHg at 25°C
• Refractive Index: 1.476
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.98±0.10(Predicted)
• BRN: 2723972
• CAS DataBase Reference: 5-AMINO-2-METHOXYBENZOTRIFLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-2-METHOXYBENZOTRIFLUORIDE(393-15-7)
• EPA Substance Registry System: 5-AMINO-2-METHOXYBENZOTRIFLUORIDE(393-15-7)

Safety Data

• Hazard Codes: Xi,T,Xn
• Statements: 20/21/22-36/37/38-52-22
• Safety Statements: 26-36/37/39
• HazardClass: TOXIC
• Hazardous Substances Data: 393-15-7(Hazardous Substances Data)

Usage

General Description

5-AMINO-2-METHOXYBENZOTRIFLUORIDE, also known as AF-121, is a chemical compound with the molecular formula C8H8F3NO. It is a white to light yellow crystalline solid and is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. 5-AMINO-2-METHOXYBENZOTRIFLUORIDE has a wide range of applications, including as an intermediate in the production of various dyes and pigments, as well as in the manufacture of organic compounds for use in materials science. It is also utilized in the development of active pharmaceutical ingredients and crop protection products. Additionally, the compound is known for its high stability and low reactivity, making it an important component in many chemical reactions and processes. Overall, 5-AMINO-2-METHOXYBENZOTRIFLUORIDE is a versatile and valuable chemical compound with diverse industrial applications.

InChI:InChI=1/C8H8F3NO/c1-13-7-3-2-5(12)4-6(7)8(9,10)11/h2-4H,12H2,1H3

Upstream product

• 654-76-2 1-methoxy-4-nitro-2-(trifluoromethyl)benzene 
• 777-37-7 4-chloro-3-(trifluoromethyl)nitrobenzene 
• 88-16-4 1-chloro-2-(trifluoromethyl)benzene 
• 7439-89-6 iron 
• 1514-11-0 4-bromo-1-methoxy-2-(trifluoromethyl)benzene 

Downstream Products

• 70338-59-9 1-Methyl-cyclopropanecarboxylic acid (4-methoxy-3-trifluoromethyl-phenyl)-amide 
• 68105-67-9 (2,4-Dinitro-naphthalen-1-yl)-(4-methoxy-3-trifluoromethyl-phenyl)-amine 
• 55225-78-0 4-(trifluoromethylsulfonyl)-3'-(trifluoromethyl)-4'-methoxycarbanilide 
• 23742-57-6 1-(4-Methoxy-3-trifluoromethyl-phenyl)-3-(4-trifluoromethyl-phenyl)-urea 
• 146886-89-7 2-(4-Methoxy-3-trifluoromethyl-phenylamino)-benzoic acid 
• 1514-11-0 4-bromo-1-methoxy-2-(trifluoromethyl)benzene 
• 1141713-96-3 C₁₀H₇F₆NO₂ 
• 1213249-78-5 C₁₆H₁₃F₃N₂O₄ 
• 1240348-83-7 C₂₇H₂₅F₃N₆O₃ 
• 1253787-11-9 N₂-[1,1-dimethyl-2-(methylthio)ethyl]-3-iodo-N₁-[4-methoxy-3-(trifluoromethyl)phenyl]-1,2-benzenedicarboxamide 
• 1345857-30-8 C₁₅H₁₄F₃NO₂ 
• 1213242-83-1 C₂₆H₂₄F₃N₇O₃ 
• 1245749-85-2 C₁₉H₁₆F₃N₃O₃ 
• 1418733-83-1 N-(4-methoxy-3-(trifluoromethyl)phenyl)-5-nitrofuran-2-carboxamide 

Relevant articles and documents

Rapid heteroatom transfer to arylmetals utilizing multifunctional reagent scaffolds

Arylmetals are highly valuable carbon nucleophiles that are readily and inexpensively prepared from aryl halides or arenes and widely used on both laboratory and industrial scales to react directly with a wide range of electrophiles. Although C-C bond formation has been a staple of organic synthesis, the direct transfer of primary amino (-NH2) and hydroxyl (-OH) groups to arylmetals in a scalable and environmentally friendly fashion remains a formidable synthetic challenge because of the absence of suitable heteroatom-transfer reagents. Here, we demonstrate the use of bench-stable N-H and N-alkyl oxaziridines derived from readily available terpenoid scaffolds as efficient multifunctional reagents for the direct primary amination and hydroxylation of structurally diverse aryl- and heteroarylmetals. This practical and scalable method provides one-step synthetic access to primary anilines and phenols at low temperature and avoids the use of transition-metal catalysts, ligands and additives, nitrogen-protecting groups, excess reagents and harsh workup conditions.

Methods of using diaminopyrimidine P2X3 and P2X2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases

Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Diaminopyrimidines as P2X3 and P2X2/3 antagonists

Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.