393513-95-6

Basic information

• Product Name: (3R)-1-(3-Chloropyridin-2-yl)-3-methylpiperazine
• Synonyms: (3R)-1-(3-Chloropyridin-2-yl)-3-methylpiperazine;(R)-1-(3-chloropyridin-2-yl)-3-methylpiperazine
• CAS NO: 393513-95-6
• Molecular Formula: C₁₀H₁₄ClN₃
• Molecular Weight: 211.6913
• Product Categories: pharmacetical
• Mol File: 393513-95-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 335.148 °C at 760 mmHg
• Flash Point: 156.492 °C
• Appearance: /
• Density: 1.157
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (3R)-1-(3-Chloropyridin-2-yl)-3-methylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-1-(3-Chloropyridin-2-yl)-3-methylpiperazine(393513-95-6)
• EPA Substance Registry System: (3R)-1-(3-Chloropyridin-2-yl)-3-methylpiperazine(393513-95-6)

Safety Data

• Hazardous Substances Data: 393513-95-6(Hazardous Substances Data)

Usage

General Description

"(3R)-1-(3-Chloropyridin-2-yl)-3-methylpiperazine" is a chemical compound with the molecular formula C11H15ClN3. It is a piperazine derivative with a methyl group and a 3-chloropyridin-2-yl functional group attached to the piperazine ring. (3R)-1-(3-Chloropyridin-2-yl)-3-methylpiperazine has potential applications in the pharmaceutical industry, particularly in the development of new drugs. It may possess pharmacological properties due to its structural features, and further research and development may reveal its potential therapeutic uses. Additionally, it may also have applications in organic synthesis and medicinal chemistry. Overall, "(3R)-1-(3-Chloropyridin-2-yl)-3-methylpiperazine" is a chemical compound with promising properties that warrant further investigation and exploration.

InChI:InChI=1/C10H14ClN3/c1-8-7-14(6-5-12-8)10-9(11)3-2-4-13-10/h2-4,8,12H,5-7H2,1H3/t8-/m1/s1

Upstream product

• 2402-77-9 2,3-dichloro-pyridine 
• 75336-86-6 (2R)-methylpiperazine 

Downstream Products

• 900184-18-1 2-[4-(5-bromo-3-chloro-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole 
• 900184-35-2 2-[4-(3-chloro-5-vinyl-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole 
• 393515-58-7 C₂₁H₂₇ClN₄S 
• 676609-11-3 N¹-(4-tert-butylphenyl)-N²-hydroxy-4-(3-chloropyridin-2-yl)-(R)-2-methylpiperazine-1-carboxamidine 

Relevant articles and documents

Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H- benzimidazoles

The vanilloid receptor-1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel that is predominantly expressed by peripheral neurons sensing painful stimuli. TRPV1 antagonists produce antihyperalgesic effects in animal models of inflammatory and neuropathic pain. Herein, we describe the synthesis and the structure-activity relationships of a series of 2-(4-pyridin-2- ylpiperazin-1-yl)-1H-benzo-[d]imidazoles as novel TRPV1 antagonists. Compound 46ad was among the most potent analogues in this series. This compound was orally bioavailable in rats and was efficacious in blocking capsaicin-induced flinch in rats in a dose-dependent manner. Compound 46ad also reversed thermal hyperalgesia in a model of inflammatory pain, which was induced by complete Freund's adjuvant (CFA).

BIARYL PIPERAZINYL-PYRIDINE ANALOGUES

Biaryl piperazinyl -pyri dine analogues are provided, of the Formula (I): wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands, for receptor localization studies.

Capsaicin receptor ligands

Disclosed are diaryl piperazines and related compounds. These compounds are selective modulators of capsaicin receptors, including human capsaicin receptors, that are, therefore, useful in the treatment of a chronic and acute pain conditions, itch and urinary incontinence. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of capsaicin receptors and as standards in assays for capsaicin receptor binding and capsaicin receptor mediated cation conductance. Methods of using the compounds in receptor localization studies are given.