395-81-3

Basic information

• Product Name: 5-Fluoro-2-nitrobenzadehyde
• Synonyms: Benzaldehyde, 5-fluoro-2-nitro-;5-FLUORO-2-NITROBENZALDEHYDE;2-NITRO-5-FLUOROBENZALDEHYDE;5-Fluoro-2-nitrobenzaldehyde 98%;5-Fluoro-2-nitrobenzaldehyde98%;5-Fluoro-2-nitrobenzadehyde;4-Fluoro-2-formylnitrobenzene
• CAS NO: 395-81-3
• Molecular Formula: C₇H₄FNO₃
• Molecular Weight: 169.11
• EINECS: 206-903-8
• Product Categories: Fluorine series;Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde
• Mol File: 395-81-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 92-94°C
• Boiling Point: 153°C 23mm
• Flash Point: >110°C
• Appearance: /
• Density: 1.443 g/cm³
• Vapor Pressure: 0.00419mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility: Insoluble in water
• Sensitive: Air Sensitive
• BRN: 1869010
• CAS DataBase Reference: 5-Fluoro-2-nitrobenzadehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-2-nitrobenzadehyde(395-81-3)
• EPA Substance Registry System: 5-Fluoro-2-nitrobenzadehyde(395-81-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38
• Safety Statements: 26-36-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 395-81-3(Hazardous Substances Data)

Usage

General Description

5-Fluoro-2-nitrobenzaldehyde is a chemical compound that consists of a benzene ring with a nitro group and a fluoro group attached to it. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. The compound is known for its strong odor and yellow color. It is also utilized in the manufacture of dyes, pigments, and other organic compounds. 5-Fluoro-2-nitrobenzaldehyde is a versatile building block in organic synthesis due to its ability to undergo various chemical reactions, such as reduction and oxidation, to produce a wide range of derivatives. However, it is important to handle this compound with care as it is toxic and can cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C8H7FO3/c1-12-7-4-5(9)2-3-6(7)8(10)11/h2-4H,1H3,(H,10,11)

Upstream product

• 13664-74-9 C₁₅H₁₄FN₃O₃ 
• 133191-70-5 5-fluoro-2-nitrobenzyl 4-methylphenyl sulfone 
• 456-48-4 3-Fluorobenzaldehyde 
• 287121-32-8 (5-Fluoro-2-nitrophenyl)-methanol 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 352-70-5 m-Fluorotoluene 
• 402-64-2 1-dichloromethyl-3-fluoro-benzene 
• 6628-86-0 5-chloro-2-nitrobenzaldehyde 
• 1404432-54-7 C₁₀H₁₁FN₂O₂ 
• 446-33-3 5-Fluoro-2-nitrotoluene 
• 82420-35-7 2-(bromomethyl)-4-fluoro-1-nitrobenzene 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 146829-56-3 2-amino-5-fluoro benzaldehyde 
• 55149-70-7 (E)-2-Cyano-3-(5-fluoro-2-nitro-phenyl)-acrylamide 
• 720-22-9 1-<5-Fluor-2-nitrophenyl>-2-nitro-ethanol 
• 603306-58-7 2-(dibutoxymethyl)-4-fluoro-1-nitrobenzene 
• 886854-01-9 4-fluoro-2-(2,2-dibromovinyl)-1-nitrobenzene 
• 908583-97-1 (Z)-3-(5-fluoro-2-nitrophenyl)-2-(4-methoxyphenyl)acrylonitrile 
• 231296-69-8 methyl (2E)-3-(5-fluoro-2-nitrophenyl)acrylate 
• 548798-23-8 5-(dimethylamino)-2-nitrobenzaldehyde 
• 548798-25-0 2-nitro-5-phenoxybenzaldehyde 
• 942614-43-9 2-(4-(N-(2-(1H-benzimidazol-2-yl)-4-(dimethylamino)phenyl)sulfamoyl)phenoxy)acetic acid ethyl ester 
• 20423-24-9 2-amino-5-(dimethylamino)benzaldehyde 
• 942614-41-7 2-(4-(N-(4-(dimethylamino)-2-formylphenyl)sulfamoyl)phenoxy)acetic acid ethyl ester 
• 908584-17-8 3-(5-fluoro-2-nitrophenyl)-2-(4-methoxyphenyl)propionitrile 
• 863870-41-1 2-(2,2-dibromovinyl)-4-fluoro-phenylamine 

Relevant articles and documents

Mild Darzens Annulations for the Assembly of Trifluoromethylthiolated (SCF3) Aziridine and Cyclopropane Structures

We report mild new annulation approaches to trisubstituted trifluoromethylthiolated (SCF3) aziridines and cyclopropanes via Darzens inspired protocols. The products of these anionic annulations, rarely studied previously, possess attractive features rendering them valuable building blocks for synthesis platforms. In this study, trisubstituted acetophenone nucleophiles bearing SCF3 and bromine substituents in their α position were shown to undergo [2 + 1] annulations with vinyl ketones and tosyl-protected imines under mild reaction conditions.

Synthetic studies on indolocarbazoles: Total synthesis of staurosporine aglycon

A synthesis of staurosporine aglycon and its analogs was achieved in a 28-36% overall yield starting from 2-methylindole. The prominent key steps for the synthesis of the indolocarbazole alkaloids involved electrocyclization and nitrene insertion reactions.

PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDES

Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.