39549-05-8

Basic information

• Product Name: Disulfide,bis[(4-nitrophenyl)methyl]
• Synonyms: Disulfide,bis(p-nitrobenzyl) (6CI,7CI); Bis(4-nitrobenzyl) disulfide; NSC 338506
• CAS NO: 39549-05-8
• Molecular Formula: C14H12 N2 O4 S2
• Molecular Weight: 336.392
• Mol File: 39549-05-8.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 534.4°Cat760mmHg
• Flash Point: 277°C
• Density: 1.434g/cm³
• CAS DataBase Reference: Disulfide,bis[(4-nitrophenyl)methyl](CAS DataBase Reference)
• NIST Chemistry Reference: Disulfide,bis[(4-nitrophenyl)methyl](39549-05-8)
• EPA Substance Registry System: Disulfide,bis[(4-nitrophenyl)methyl](39549-05-8)

Safety Data

• Hazardous Substances Data: 39549-05-8(Hazardous Substances Data)

Usage

General Description

Disulfide, bis[(4-nitrophenyl)methyl] is a chemical compound with the molecular formula C20H18N2O4S2. It is composed of two 4-nitrobenzyl groups connected by a disulfide bridge. Disulfide,bis[(4-nitrophenyl)methyl] is often used as a reagent in organic synthesis and as a building block in the creation of complex molecules. It is commonly utilized in the manufacture of pharmaceuticals, agrochemicals, and materials science. The compound's unique structure and properties make it a valuable tool in various chemical reactions and processes. However, it is important to handle this chemical with caution, as it can be hazardous if not properly handled and stored.

Upstream product

• 100-14-1 4-nitrobenzyl chloride 
• 497-19-8 sodium carbonate 
• 619-73-8 4-nitrobenzyl chloride 
• 68-12-2 N,N-dimethyl-formamide 
• 94039-56-2 sodium 4-nitrobenzylsulfanesulfonate 
• 26798-33-4 (p-nitrophenyl)methanethiol 
• 7647-01-0 hydrogenchloride 
• 861383-71-3 6-iodo-6-methoxy-1,4-dimethyl-2-(4-nitro-benzylmercapto)-1,6-dihydro-pyrimidine 
• 64-17-5 ethanol 
• 4357-96-4 S-(4-nitro-benzyl)-isothiourea; hydrochloride 
• 95416-92-5 C₂₁H₁₈N₂O₆S₃ 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 94215-35-7 S-(4-Nitro-benzylmercapto)-thioglykolsaeure-methylester 
• 19457-06-8 benzyl-dithiocarbamic acid-(4-nitro-benzyl ester) 

Downstream Products

• 102192-28-9 tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-(4-nitrobenzylthio)-4-hydroxy-1-dethia-2-thiacepham-4-carboxylate 
• 102142-87-0 tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-(4-nitrobenzylthio)-1-dethia-2-thia-3-cephem-4-carboxylate 
• 102141-70-8 7β-<2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-(4-nitrobenzylthio)-1-dethia-2-thia-3-cephem-4-carboxylic acid 
• 859793-64-9 C₇H₆ClNO₂S 
• 4025-75-6 (4-nitrophenyl)methanesulfonyl chloride 
• 15563-48-1 N,N-dimethyl-p-nitro-thiobenzamide 
• 221910-92-5 2,8-bis-(4-nitro-benzyldisulfanylmethyl)-6H,12H-5,11-methano-dibenzo[b,f][1,5]diazocine 
• 35785-42-3 (2R,3S,4S,5R,6S)‐2‐(acetoxymethyl)‐6‐((4‐nitrobenzyl)thio)tetrahydro‐2H‐pyran‐3,4,5‐triyl triacetate 
• 35785-63-8 2,3,4,6-tetra-O-acetyl-1-deoxy-1-(p-nitrobenzylthio)-β-D-glucopyranose 
• 22868-34-4 2-(4-nitrophenyl)benzothiazole 
• 221910-91-4 4-(4-nitro-benzyldisulfanylmethyl)-phenylamine 
• 6310-10-7 4-nitrobenzaldehyde hydrazone 

Relevant articles and documents

Diarylmethylene disulfide compound as well as preparation method and application thereof

The invention relates to the technical field of medicines and in particular relates to a diarylmethylene disulfide compound as well as a preparation method and application thereof. An experiment result shows that on a cell model, the diarylmethylene disulfide compound provided by the invention has an effect of inhibiting neurotoxicity caused by excessive glutamic acid and an effect of inhibiting neurotoxicity caused by hydrogen peroxide; the diarylmethylene disulfide compound also has a platelet aggregation resisting effect and can be used for reducing a cerebral infarct area in a mouse MCAO (Middle Cerebral Artery Occlusion) model. The results show that the diarylmethylene disulfide compound provided by the invention can have prevention and/or treatment effects on cerebral stroke.

The synthesis of symmetrical disulfides by reacting organic halides with Na2S2O3·5H2O in DMSO

A one-pot, and scalable method to prepare symmetric disulfides from their corresponding primary, secondary, allylic, and benzylic halides has been developed. In this method, a disulfide is synthesized by reacting an alkyl halide with Na2S2O3·5H2O at 60-70 °C in DMSO.

Deep eutectic mixture catalysed the synthesis of disulfides using Bunte salts as thiol surrogates

Bunte salts, easily prepared from odourless sodium thiosulfates and various alkyl and aryl halides, acted as thiol surrogates for preparation of disulfides in the presence of hydrogen peroxide and a Bronsted-acidic deep eutectic mixture. The reaction proceeded smoothly to give the corresponding disulfide products in moderate to good yields, leaving odourless sodium bisulfite and water as the by-products. Moreover, this catalytic system could be readily recovered and reused several times without significant loss in activity.