39577-43-0

Basic information

• Product Name: 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine
• Synonyms: CCP;LABOTEST-BB LT00441048;1-(3-CHLOROPHENYL)-4-(3-CHLOROPROPYL)PIPERAZINE;1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine (CCP);piperazine hydrochloride/1-(3-chlorophenyl)-4-(3-chloropropyl)-piperazine hydrochloride;1-(3-Chlorophenyl)-4-(3-chloro;1-(3-CHLOROPHENYL)-4-(3-CHLOROPROPYL)PIPERAZINE HYDROCHLORIDE 97%;Piperazine, 1-(3-chlorophenyl)-4-(3-chloropropyl)-
• CAS NO: 39577-43-0
• Molecular Formula: C₁₃H₁₈Cl₂N₂
• Molecular Weight: 309.67
• EINECS: 254-529-9
• Product Categories: Piperazines;BUILDING BLOCKS;Piperaizine;Piperazine derivates;Nutritional fortification substances
• Mol File: 39577-43-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 199 °C
• Boiling Point: 395.8 °C at 760 mmHg
• Flash Point: 193.2 °C
• Appearance: /
• Density: 1.186
• Vapor Pressure: 1.79E-06mmHg at 25°C
• Refractive Index: 1.553
• PKA: 7.20±0.10(Predicted)
• Water Solubility: 140.1mg/L at 25℃
• CAS DataBase Reference: 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine(39577-43-0)
• EPA Substance Registry System: 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine(39577-43-0)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 24/25
• Hazardous Substances Data: 39577-43-0(Hazardous Substances Data)

Usage

Description

1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine is an organic compound with the chemical formula C18H20Cl2N2. It is a white to beige powder and is known for its use in the pharmaceutical industry.

Uses

1. Used in Pharmaceutical Industry:
1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine is used as an intermediate in the synthesis of various pharmaceutical compounds.
2. Used in the Preparation of Trazodone:
In the method of continuous flow process, 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine is used as a key intermediate for the preparation of Trazodone, which is an antidepressant medication.
3. Used in the Preparation of Benzoaza-Alkylaryl Piperazine Derivatives:
1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine is used as a starting material for the synthesis of Benzoaza-Alkylaryl Piperazine derivatives. These derivatives are utilized in the treatment of mental diseases, offering potential therapeutic benefits for patients suffering from various psychiatric conditions.
4. Used in Chemical Research:
Due to its unique chemical structure, 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine may also be employed in chemical research for the development of new compounds and materials with potential applications in various industries.

InChI:InChI=1/C13H18Cl2N2/c14-5-2-6-16-7-9-17(10-8-16)13-4-1-3-12(15)11-13/h1,3-4,11H,2,5-10H2

Upstream product

• 109-70-6 1.3-chlorobromopropane 
• 6640-24-0 N-(m-chlorophenyl)piperazine 
• 32229-98-4 1-(3-hydroxy-n-propyl)-4-(3-chlorophenyl)-piperazine 
• 13078-15-4 1-(3-chlorophenyl)piperazine hydrochloride 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 112551-89-0 1-[4-(3-chloro-phenyl)-piperazino]-3-(4-phenyl-piperazino)-propane 
• 6320-28-1 1-[4-(3-chloro-phenyl)-piperazino]-3-(4-m-tolyl-piperazino)-propane 
• 114694-58-5 1-[4-(3-chloro-phenyl)-piperazino]-3-(4-p-tolyl-piperazino)-propane 
• 114694-57-4 1-[4-(3-chloro-phenyl)-piperazino]-3-(4-o-tolyl-piperazino)-propane 
• 115098-03-8 1-[4-(3-chloro-phenyl)-piperazino]-3-[4-(4-chloro-phenyl)-piperazino]-propane 
• 6323-10-0 1-[4-(2-chloro-phenyl)-piperazino]-3-[4-(3-chloro-phenyl)-piperazino]-propane 
• 91532-01-3 3-<3-<4-(3-chlorophenyl)piperazin-1-yl>-propyl>-1,2,3-benzotriazin-4(3H)-one 
• 113642-20-9 4-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propoxy}-benzo[d][1,2,3]triazine 
• 91532-39-7 3-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-6-methyl-3H-benzo[d][1,2,3]triazin-4-one 
• 91532-38-6 7-Chloro-3-{3-[4-(3-chloro-phenyl)-piperazin-1-yl]-propyl}-3H-benzo[d][1,2,3]triazin-4-one 
• 113675-73-3 3-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-6-nitro-3H-benzo[d][1,2,3]triazin-4-one 
• 113675-63-1 3-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-3H-pyrido[3,4-d][1,2,4]triazin-4-one 
• 113642-28-7 3-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-3H-pyrido[3,2-d][1,2,3]triazin-4-one 
• 103076-63-7 2-(3-(4-(3-chlorophenyl)piperazino)propoxy)benzaldehyde 

Relevant articles and documents

Synthesis and pharmacological screening of some N-(4-substituted-piperazin-1-ylalkyl)-3,4-pyrroledicarboximides

As an extension of our previous work we describe the synthesis and pharmacological investigation of a new series of derivatives of pyrrole-3,4-dicarboximide possessing the 4-substituted-piperazin-1-ylalkyl group linked to the imide nitrogen. The products were evaluated for acute toxicity, and effectiveness in a series of CNS and arterial blood pressure tests. The preliminary pharmacological screening was determined in animal models. Several compounds demonstrated moderate to high analgesic activity in the 'writhing syndrome' test (5f-1/640 LD50). Some of the structure-activity relationships are also discussed.

CONTINUOUS PROCESS FOR THE PREPARATION OF TRAZODONE

The present invention relates to an improved process for the preparation of trazodone. In particular, the present invention relates to a continuous process for the preparation of trazodone. More in particular, the present invention relates to a new method for the preparation of trazodone, said method comprising at least one step consisting of a continuous process performed in a flow reactor.

Synthesis, characterization, and anticancer studies of S and N alkyl piperazine-substituted positional isomers of 1,2,4-triazole derivatives

A series of 3-[3-[4-(substituted)-1-cyclicamine] propyl]thio-5- substituted[1,2,4]triazoles (8a-m) and 2-[3-[4-(substituted)-1-cyclicamine] propyl]-5-(substituted)-2,4-dihydro-3H[1,2,4]triazole-3-thiones (9a-h) were synthesized with good yields starting from corresponding carboxylic acids using two different methods. The cytotoxicity studies of these derivatives were studied against five different human cancer cell lines. Six compounds had shown good anticancer activity. The triazole derivatives, 9d, 8j, and 8i were most potent particularly against U937 and HL-60 cells. The cytotoxic potency of the compounds varied between the cell lines suggesting that a structural property of these compounds as possible determinant of their biological activity. Springer Science+Business Media 2013.