396-12-3

Basic information

• Product Name: Acetamide, N-[2-nitro-4-(trifluoromethyl)phenyl]-
• CAS NO: 396-12-3
• Molecular Formula: C9H7F3N2O3
• Molecular Weight: 248.161
• Mol File: 396-12-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[2-nitro-4-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[2-nitro-4-(trifluoromethyl)phenyl]-(396-12-3)
• EPA Substance Registry System: Acetamide, N-[2-nitro-4-(trifluoromethyl)phenyl]-(396-12-3)

Safety Data

• Hazardous Substances Data: 396-12-3(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 400-98-6 4-trifluoromethyl-2-nitroaniline 
• 75-36-5 acetyl chloride 
• 64-19-7 acetic acid 
• 455-14-1 4-trifluoromethylphenylamine 
• 349-97-3 4-(trifluromethyl)acetanilide 

Downstream Products

• 98-17-9 3-Trifluoromethylphenol 
• 98-16-8 3-trifluoromethylaniline 
• 98-46-4 3-trifluoromethylnitrobenzene 
• 543740-74-5 2-iodo-6-nitro-4-(trifluoromethyl)aniline 
• 51093-74-4 1-azido-2-nitro-4-(trifluoromethyl)benzene 
• 313485-95-9 2-phenylazo-4-(trifluoromethyl)acetanilide 
• 313485-97-1 6-trifluoromethyl-N-phenyl-1H-benzo[d]imidazol-1-amine 
• 313485-96-0 2-phenylazo-4-(trifluoromethyl)aniline 
• 79759-90-3 1-methyl-2-oxo-5-(trifluoromethyl)-2,3-dihydrobenzimidazole 
• 35203-49-7 N¹-methyl-4-(trifluoromethyl)benzene-1,2-diamine 
• 20200-22-0 α,α,α-Trifluoro-N-methyl-6-nitro-p-toluidine 
• 300698-92-4 N-methyl-N-[2-nitro-4-(trifluoromethyl)phenyl]acetamide 
• 97051-69-9 N-(2-amino-4-(trifluoromethyl)phenyl)acetamide 
• 400-98-6 4-trifluoromethyl-2-nitroaniline 

Relevant articles and documents

PIII/PV=O Catalyzed Cascade Synthesis of N-Functionalized Azaheterocycles

An organocatalytic method for the modular synthesis of diverse N-aryl and N-alkyl azaheterocycles (indoles, oxindoles, benzimidazoles, and quinoxalinediones) is reported. The method employs a small-ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane P-oxide) and a hydrosilane reductant to drive the conversion of ortho-functionalized nitroarenes into azaheterocycles through sequential intermolecular reductive C?N cross coupling with boronic acids, followed by intramolecular cyclization. This method enables the rapid construction of azaheterocycles from readily available building blocks, including a regiospecific approach to N-substituted benzimidazoles and quinoxalinediones.

Preparation method of 3-hydroxyphenyl trifluoromethyl ether

The invention provides a preparation method of 3-hydroxyphenyl trifluoromethyl ether. The preparation method comprises the following steps: taking 4-trifluoromethoxyaniline as a raw material; and successively carrying out acetylation, nitrification, deacetylation, deaminizating, reduction and hydrolysis reaction on the 4-trifluoromethoxyaniline to obtain the 3-hydroxyphenyl trifluoromethyl ether. The preparation method is high in yield of products, simple to operate and low in production cost; and industrialization is facilitated.

SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS

Amine substituted pyridine and pyrazine compounds and forms thereof that inhibit the function and reduce the level of B -cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.