39620-04-7Relevant articles and documents
3-Substituted 2-isocyanopyridines as versatile convertible isocyanides for peptidomimetic design
Ballet, Steven,Elsocht, Mathias,Hollanders, Charlie,Jida, Mouhamad,Maes, Bert U. W.,Renders, Evelien,Van der Poorten, Olivier
supporting information, p. 6863 - 6866 (2021/07/19)
We report the use of 3-substituted 2-isocyanopyridines as convertible isocyanides in Ugi four-component reactions. TheN-(3-substituted pyridin-2-yl)amide Ugi products can be cleaved by amines, alcohols, and water with Zn(OAc)2as a catalyst. In addition, the applicability of the method was demonstrated in constrained di-/tripeptides bearing acid and base sensitive protective groups obtainedviaUgi-4CR post-condensation modifications.
A method for preparation of 2-amino-5-chloro-pyridine
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Paragraph 0020; 0021; 0022, (2017/03/24)
The invention provides a method for preparation of 2-amino-5-chloro-pyridine and belongs to the technical field of fine organic synthesis. 2-amino-5-chloro-pyridine is prepared by adopting 2-aminopyridine as a raw material and using hydrochloric acid and sodium hypochlorite for an oxidative chlorination reaction. The method mainly includes the following steps: at 10 DEG C, slowly and dropwise adding a certain amount of concentrated hydrochloric acid in a mixed solution of 2-aminopyridine and NaClO, conducting a reaction at constant temperature for 2 hours, increasing the temperature to 25 DEG C for continuing the reaction for 4 hours, regulating the pH of a reaction product, extracting the reaction product with dichloroethane, and conducting separation to obtain 2-amino-5-chloro-pyridine. The yield of 2-amino-5-chloro-pyridine is up to 72%. The method has the advantages that the cheap NaClO solution generated by chlorination of tail gas by chlorine gas and hydrochloric acid are used as chlorinating agents, the cost is thus reduced, and the comprehensive utilization of resources is achieved; the reaction conditions are mild, direct use of chlorine gas is avoided, safety is high, and pollution is little.