39635-11-5

Basic information

• Product Name: 3,4-DIHYDROXYBENZHYDRAZIDE
• Synonyms: LABOTEST-BB LT00455293;3,4-DIHYDROXYBENZHYDRAZIDE;PROTOCATECHUIC HYDRAZIDE;3,4-dihydroxybenzohydrazide;3,4-DIHYROXYBENZHYDRAZIDE;3,4-DIHYDROXYBENZHYDRAZIDE 97%;4-Dihydroxybenzhydrazide
• CAS NO: 39635-11-5
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.15
• EINECS: 254-550-3
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 39635-11-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 268°C
• Appearance: /
• Density: 1.477 g/cm³
• Refractive Index: 1.67
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• BRN: 2642968
• CAS DataBase Reference: 3,4-DIHYDROXYBENZHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIHYDROXYBENZHYDRAZIDE(39635-11-5)
• EPA Substance Registry System: 3,4-DIHYDROXYBENZHYDRAZIDE(39635-11-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot
• HazardClass: IRRITANT
• Hazardous Substances Data: 39635-11-5(Hazardous Substances Data)

Usage

General Description

3,4-Dihydroxybenzhydrazide, also known as DHBA, is a chemical compound with the molecular formula C7H8N2O3. It is a white to off-white crystalline powder that is primarily used as a chelating agent and antioxidant in various industrial and commercial applications. DHBA is also known for its use in medical research and pharmaceutical development, particularly for its potential as a therapeutic agent for conditions related to oxidative stress. Additionally, it is used as a precursor in the synthesis of various organic compounds and has been studied for its potential use in the treatment of neurodegenerative diseases and cancer. DHBA is a versatile compound with various potential applications in different fields due to its unique chemical properties.

InChI:InChI=1/C7H8N2O3/c8-9-7(12)4-1-2-5(10)6(11)3-4/h1-3,10-11H,8H2,(H,9,12)

Upstream product

• 3943-89-3 Ethyl protocatechuate 
• 2150-43-8 3,4-dihydroxybenzoic acid methyl ester 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 83759-00-6 3,4-dihydroxybenzoyl chloride 

Downstream Products

• 19949-24-7 4-(5-amino-[1,3,4]oxadiazol-2-yl)-benzene-1,2-diol 
• 134368-07-3 1-(3,4-dihydroxybenzoylamino)-4-thiopyridone 
• 141992-38-3 Glyoxylsaeure-3,4-dihydroxybenzoylhydrazon 
• 136248-91-4 3,4-Dihydroxy-benzoic acid N'-(2-bromo-acetyl)-hydrazide 
• 807628-34-8 C₃₁H₃₃N₅O₇Si 
• 141992-39-4 Glyoxylsaeure-3,4-di-(methoxycarbonyloxy)-benzoylhydrazon 
• 141992-40-7 Glyoxylsaeure-3,4-diethoxycarbonyloxy-benzoylhydrazon 
• 141992-30-5 (2S,5R,6R)-6-(2-{2-[(3,4-Bis-methoxycarbonyloxy-benzoyl)-hydrazono]-acetylamino}-2-phenyl-acetylamino)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 
• 141992-31-6 (2S,5R,6R)-6-(2-{2-[(3,4-Bis-ethoxycarbonyloxy-benzoyl)-hydrazono]-acetylamino}-2-phenyl-acetylamino)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 
• 141992-32-7 (2S,5R,6R)-6-[2-{2-[(3,4-Bis-methoxycarbonyloxy-benzoyl)-hydrazono]-acetylamino}-2-(4-hydroxy-phenyl)-acetylamino]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 
• 141992-33-8 (2S,5R,6R)-6-[2-{2-[(3,4-Bis-ethoxycarbonyloxy-benzoyl)-hydrazono]-acetylamino}-2-(4-hydroxy-phenyl)-acetylamino]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 
• 19949-34-9 1,2-diacetoxy-4-(5-acetylamino-[1,3,4]oxadiazol-2-yl)-benzene 
• 19938-34-2 4-(5-benzoylamino-[1,3,4]oxadiazol-2-yl)-1,2-bis-benzoyloxy-benzene 
• 150191-76-7 4-(5-amino-1H-1,2,4-triazol-3-yl)pyrocatechol 

Relevant articles and documents

Synthesis, protolytic equilibria, and antimicrobial action of nifuroxazide analogs

The present paper reports on the synthesis of four hydrazones derived from 5-nitro-2-furfural, 5-nitro-2-thiophenal, isoniazid, 2,4- and 3,4-dihydroxy-N′-methylenebenzohydrazide. The acid-base dissociation constants of these compounds were determined in an aqueous solution. The protolytic equilibria-related ability of hydrazones to “sense” anions in dimethyl sulfoxide-containing water of different concentrations is studied using spectrophotometry, NMR spectroscopy, and quantum chemistry methods. The antimicrobial action of the hydrazones was tested and compared with that of the known drug nifuroxazide.

Aromatic acyl hydrazone derivative and application thereof as NA inhibitor

The invention relates to an aromatic acyl hydrazone derivative as shown in a structural formula I, pharmaceutically acceptable salt and a pharmaceutical composition thereof, and application of the aromatic acyl hydrazone derivative and the pharmaceutically acceptable salt and the pharmaceutical composition in preparation of an influenza virus neuraminidase inhibitor, wherein R is one of trifluoromethyl, nitryl, 3-methyl-4-nitryl, 3-hydroxyl-4-nitryl, 3-nitryl-4-hydroxyl, hydroxyl, dihydroxyl, dinitryl, 3-methoxy-4-hydroxyl or trihydroxyl; Y is selected from hydroxyl, dihydroxyl, 2-hydroxyl-3-methoxy, 2-hydroxyl-4-methoxy,2-hydroxyl-5-methoxy,2-hydroxyl-6-methoxy,3-hydroxyl-2-methoxy,3-hydroxyl-4-methoxy,3-hydroxyl-5-methoxy,3-hydroxyl-6-methoxy,4-hydroxyl-2-methoxy,4-hydroxyl-3-methoxy,4-hydroxyl-3,5-dimethoxy, trihydroxyl, 4-hydroxyl-3-ethoxy, or 4-hydroxyl-3,5-dimethoxy; w is selected from CH or N; and z is selected from CH or N.

Design, synthesis, and evaluation of simple phenol amides as ERRγ agonists

Herein we report the design and synthesis of a series of simple phenol amide ERRγ agonists based on a hydrazone lead molecule. Our structure activity relationship studies in this series revealed the phenol portion of the molecule to be required for activity. Attempts to replace the hydrazone with more suitable chemotypes led to a simple amide as a viable alternative. Differential hydrogen-deuterium exchange experiments were used to help understand the structural basis for binding to ERRγ and aid in the development of more potent ligands.