397-50-2

Basic information

• Product Name: 3-(trifluoromethyl)-10H-phenothiazine
• CAS NO: 397-50-2
• Molecular Formula: C₁₃H₈F₃NS
• Molecular Weight: 267.2695
• Mol File: 397-50-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 362.9°C at 760 mmHg
• Flash Point: 173.3°C
• Density: 1.369g/cm³
• Vapor Pressure: 1.87E-05mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 3-(trifluoromethyl)-10H-phenothiazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(trifluoromethyl)-10H-phenothiazine(397-50-2)
• EPA Substance Registry System: 3-(trifluoromethyl)-10H-phenothiazine(397-50-2)

Safety Data

• Hazardous Substances Data: 397-50-2(Hazardous Substances Data)

Upstream product

• 7641-28-3 formic acid-[2-(2-nitro-4-trifluoromethyl-phenylsulfanyl)-anilide] 
• 322-72-5 acetic acid-[2-(2-nitro-4-trifluoromethyl-phenylsulfanyl)-anilide] 
• 322-71-4 2-[(4-trifluoromethyl-2-nitrophenyl)thio]aniline 
• 454-78-4 3-bromo-4-chlorobenzotrifluoride 
• 137-07-5 2-amino-benzenethiol 
• 6320-02-1 o-bromothiophenol 
• 372517-97-0 N-(2-iodo-4-(trifluoromethyl)phenyl)acetamide 
• 6320-03-2 2-chlorothiphenol 
• 75091-99-5 4-(trifluoromethyl)cyclohexan-1-one 

Relevant articles and documents

Potassium carbonate-mediated tandem C-S and C-N coupling reaction for the synthesis of phenothiazines under transition-metal-free and ligand-free conditions

An efficient potassium carbonate-mediated tandem C-S and C-N coupling reaction between N-(2-iodophenyl)acetamides and 2-halo-benzenethiols has been developed. This protocol affords a simple and efficient approach for the construction of phenothiazine derivatives without the need for addition of transition-metal catalyst or ligand for the first time. Furthermore, the reaction can be easily performed on a large scale.

Synthesis of phenothiazines via ligand-free CuI-catalyzed cascade C-S and C-N coupling of aryl ortho-dihalides and ortho-aminobenzenethiols

A ligand-free CuI-catalyzed cascade C-S and C-N cross coupling of (hetero)aryl ortho-dihalides and ortho-aminobenzenethiols has been developed, and various phenothiazines were synthesized with excellent regioselectivity. A possible mechanism is proposed for the cascade coupling.