39892-24-5

Basic information

• Product Name: 3-(2-CHLORO-ETHYL)-PYRIDINE
• Synonyms: 3-(2-CHLORO-ETHYL)-PYRIDINE
• CAS NO: 39892-24-5
• Molecular Formula: C7H8ClN
• Molecular Weight: 141.6
• Mol File: 39892-24-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(2-CHLORO-ETHYL)-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-CHLORO-ETHYL)-PYRIDINE(39892-24-5)
• EPA Substance Registry System: 3-(2-CHLORO-ETHYL)-PYRIDINE(39892-24-5)

Safety Data

• Hazardous Substances Data: 39892-24-5(Hazardous Substances Data)

Usage

General Description

3-(2-chloro-ethyl)-pyridine, also known as 2-chloroethylpyridine, is a chemical compound with the molecular formula C7H8ClN. It is a colorless to light yellow liquid that is commonly used in the production of pesticides, pharmaceuticals, and other organic compounds. It is a highly flammable and toxic substance that should be handled with care. It has a characteristic odor and is soluble in organic solvents like benzene and ether. Its primary use is as an intermediate in the synthesis of various pharmaceuticals and agricultural chemicals. It is important to use proper protective equipment and adhere to safety protocols when working with 3-(2-chloro-ethyl)-pyridine due to its hazardous nature.

Upstream product

• 6293-56-7 3-pyridinylethanol 
• 497-19-8 sodium carbonate 
• 39931-77-6 pyridin-3-yl-acetic acid ethyl ester 
• 6419-36-9 3-pyridineacetic acid hydrochloride 
• 39998-25-9 methyl pyridine-3-acetate 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH APJ RECEPTOR ACTIVITY

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize) the apelin receptor (also referred to herein as the APJ receptor; gene symbol "APLNR"). This disclosure also features compositions containing the same as well as other methods of using and making the same. The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which a decrease in APJ receptor activity (e.g., repressed or impaired APJ receptor signaling; e.g., repressed or impaired apelin-APJ receptor signaling) or downregulation of endogenous apelin contributes to the pathology and/or symptoms and/or progression of the disease, disorder, or condition. Non-limiting examples of such diseases, disorders, or conditions include: (i) cardiovascular disease; (ii) metabolic disorders; (iii) diseases, disorders, and conditions associated with vascular pathology; and (iv) organ failure; (v) diseases, disorders, and conditions associated with infections (e.g., microbial infections); and (vi) diseases, disorders, or conditions that are sequela or comorbid with any of the foregoing or any disclosed herein. More particular non-limiting examples of such diseases, disorders, or conditions include pulmonary hypertension (e.g., PAH); heart failure; type II diabetes; renal failure; sepsis; and systemic hypertension.

Optionally substituted pyrido[2,3-d]pyridine-2,4(1H,3H)-diones and pyrido[2,]pyrimidine-2(1H,3H)-ones

The present invention relates to optionally substituted pyrido[2,3-d]pyrimidine-2,4(1H,3H)-diones or optionally substituted pyrido[2,3-d]pyrimidine-2(1H,3H)-ones, i.e., compounds of Formula I: STR1 wherein: Y is --CH2 -- or --C(O)--; R1 is hydrogen or --(CH2)n --R7, wherein: R7 is aryl or heteroaryl, and n is 1 or 2, provided that when Y is --C(O)--, R7 is heteroaryl; and R2, R3, R4, R5 and R6 are hydrogen, or one is selected from lower alkyl, halo, carboxy, methoxycarbonyl, carbamoyl, methylcarbamoyl, di-methylcarbamoyl, methylcarbonyl, methylthio, methylsulfinyl, methylsulfonyl, hydroxymethyl, amino, trifluoromethyl, cyano or nitro; or R2, R3, R4 and R5 are independently selected from hydrogen, lower alkyl, nitro, chloro, fluoro, methoxycarbonyl or methylcarbonyl, provided at least one is hydrogen, and R6 is hydrogen; or a pharmaceutically acceptable ester, ether or salt thereof.