39943-56-1

Basic information

• Product Name: 3,5-DICHLOROPHENYLHYDRAZINE
• Synonyms: 3,5-DICHLOROPHENYLHYDRAZINE;3,5-Dichlorophenylhydrazine,98%
• CAS NO: 39943-56-1
• Molecular Formula: C₆H₆Cl₂N₂
• Molecular Weight: 177.03
• EINECS: -0
• Mol File: 39943-56-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 111-114°C
• Boiling Point: 286℃
• Flash Point: 127℃
• Appearance: /
• Density: 1.475
• Vapor Pressure: 0.0027mmHg at 25°C
• Refractive Index: 1.665
• PKA: 4?+-.0.10(Predicted)
• BRN: 3126965
• CAS DataBase Reference: 3,5-DICHLOROPHENYLHYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DICHLOROPHENYLHYDRAZINE(39943-56-1)
• EPA Substance Registry System: 3,5-DICHLOROPHENYLHYDRAZINE(39943-56-1)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 2811
• HazardClass: IRRITANT-HARMFUL
• Hazardous Substances Data: 39943-56-1(Hazardous Substances Data)

Usage

General Description

3,5-Dichlorophenylhydrazine is a chemical compound with the molecular formula C6H6Cl2N2. It is a hydrazine derivative and is commonly used in organic synthesis as a reagent for the preparation of various drugs and agrochemicals. 3,5-DICHLOROPHENYLHYDRAZINE is a colorless to light yellow solid that is insoluble in water but soluble in organic solvents. It is also a potent inhibitor of monoamine oxidase (MAO) and has potential applications in the treatment of depression and other neurological disorders. Additionally, 3,5-Dichlorophenylhydrazine is also used in the manufacture of dyes, pesticides, and as a reagent in the determination of ketones and aldehydes in organic chemistry. However, it is important to handle this compound with care, as it is toxic and may cause irritation to the eyes, skin, and respiratory system if not properly handled.

InChI:InChI=1/C6H6Cl2N2/c7-4-1-5(8)3-6(2-4)10-9/h1-3,10H,9H2

Upstream product

• 137273-10-0 N'-(3,5-Dichloro-phenyl)-hydrazinecarboxylic acid 2,2,2-trichloro-ethyl ester 
• 626-43-7 3,5-Dichloroaniline 
• 108-70-3 1,3,5-trichlorobenzene 

Downstream Products

• 4990-88-9 6-Chlor-6-desoxy-D-mannose-(3,5-dichlor-phenylhydrazon) 
• 96423-48-2 N-(3,5-Dichloro-phenyl)-N'-(4,5-dihydro-thiazol-2-yl)-hydrazine; hydrobromide 
• 96423-59-5 N-(3,5-Dichloro-phenyl)-N'-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-hydrazine; hydrochloride 
• 77625-66-2 2-(3,5-Dichloro-phenyl)-1,4-dihydro-2H-thiochromeno[4,3-c]pyrazol-3-one 
• 73594-97-5 5-Amino-4-cyan-1-(3,5-dichlorphenyl)pyrazol 
• 24095-97-4 C₈H₉Cl₂N₃S 
• 76982-30-4 5-amino-1-(3,5-dichlorophenyl)-3-methyl-1H-pyrazole-4-carbonitrile 
• 176036-82-1 N-(3,5-dichlorophenyl)benzamide (3,5-dichlorophenyl)hydrazone 
• 96423-39-1 1-(3,5-Dichlor-phenyl)-thiosemicarbazid 
• 541-73-1 1,3-Dichlorobenzene 
• 1026915-45-6 3-[1-(3,5-dichloro-phenyl)-3-(3,4-dichloro-phenyl)-1H-pyrazol-4-yl]-acrylic acid 
• 76982-38-2 4-Amino-1-(3,5-dichlorphenyl)-3-methyl-1H-pyrazolo<3,4-d>pyrimidin 
• 135108-67-7 4-Amino-1-(3,5-dichloro-phenyl)-5-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-6-one 
• 103855-01-2 ethyl 2-[2-(3,5-dichlorophenyl)hydrazinylidene]propanoate 

Relevant articles and documents

Synthesis and biological evaluation of benzimidazole phenylhydrazone derivatives as antifungal agents against phytopathogenic fungi

A series of benzimidazole phenylhydrazone derivatives (6a-6ai) were synthesized and characterized by 1H-NMR, ESI-MS, and elemental analysis. The structure of 6b was further confirmed by single crystal X-ray diffraction as (E)-configuration. All the compounds were screened for antifungal activity against Rhizoctonia solani and Magnaporthe oryzae employing a mycelium growth rate method. Compound 6f exhibited significant inhibitory activity against R. solani and M. oryzae with the EC50 values of 1.20 and 1.85 μg/mL, respectively. In vivo testing demonstrated that 6f could effectively control the development of rice sheath blight (RSB) and rice blast (RB) caused by the above two phytopathogens. This work indicated that the compound 6f with a benzimidazole phenylhydrazone scaffold could be considered as a leading structure for the development of novel fungicides.

Process for preparing pesticidal intermediates

The invention relates to processes for the preparation of compounds of formula (I) wherein R1and R2each independently represent a halogen atom.

Antiimplantation Agents: Part I - 1-Arylthiosemicarbazides

Several 1-arylthiosemicarbazides, 2-arylhydrazinothiazolines and 2-arylhydrazinodihydrothiazines have been examined for their antiimplantation activity in rats.Among the active compounds, 4-methyl-1-(3,5-bistrifluoromethylphenyl)thiosemicarbazide (3, C 2696-Go) and the corresponding 4,4-dimethyl (47), ethyl (4), n-butyl (5) and allyl (6) derivatives completely inhibit implantation at doses 10, 3, 20, 20 and 30 mg/kg respectively.The 3,4-dichlorophenyl analogue (32) is effective at a dose of 30 mg/kg. 2-(3,5-Bistrifluoromethylphenyl)hydrazinothiazoline (51) and the corresponding dihydrothiazine (63) show a weaker activity.The biological profile of C 2696-Go has been investigated in detail.It appears to prevent implantation by its antiuterotropic activity and ability to inhibit desiduoma formation.