4005-51-0 Usage
Description
2-Amino-1,3,4-thiadiazole is a chemical compound belonging to the thiadiazole family, characterized by its white to light yellow crystalline powder form. It is known for its unique chemical properties, which allow it to form charge transfer complexes with various acceptors such as 2,3-dichloro-5,6-dicyano-p-benzoquinone, p-chloranil, o-chloranil, p-bromanil, and chloranilic acid.
Uses
Used in Pharmaceutical Industry:
2-Amino-1,3,4-thiadiazole is used as an intermediate for ceftraoline, a cephalosporin antibiotic. It plays a crucial role in the synthesis of this antibiotic, contributing to its effectiveness in treating bacterial infections.
Used in Anticancer Applications:
2-Amino-1,3,4-thiadiazole is also recognized for its antitumor properties, making it a potential candidate for the development of new cancer treatments. Its effects on purine and pyrimidine ribonucleotide pools of L1210 ascites cells in vivo have been reported, indicating its potential role in modulating cellular processes related to cancer.
Used in Fungicide Industry:
2-Amino-1,3,4-thiadiazole exhibits fungicidal properties, making it a valuable component in the development of fungicides. These fungicides can be used in agriculture to protect crops from fungal infections, thereby increasing crop yield and ensuring food security.
Safety Profile
Poison by subcutaneous andintraperitoneal routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits very toxic fumes of NOx and SOx.
Check Digit Verification of cas no
The CAS Registry Mumber 4005-51-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,0 and 5 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4005-51:
(6*4)+(5*0)+(4*0)+(3*5)+(2*5)+(1*1)=50
50 % 10 = 0
So 4005-51-0 is a valid CAS Registry Number.
InChI:InChI=1/C2H3N3S/c3-2-5-4-1-6-2/h1H,(H2,3,5)
4005-51-0Relevant articles and documents
Antitumor activity of 2-acylamino-1,3,4-thiadiazoles and related compounds
Miyahara,Nakadate,Sueyoshi,Tanno,Kamiya
, p. 4402 - 4406 (1982)
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Synthesis of Emodin Amide Derivatives Containing 1,3,4-Thiadiazole and Their Inhibitory Activity on Vibrio harveyi
Cao, Lian-Gong,Cao, Zhi-Ling,Chen, Chao,Jiang, Kai-Jun,Liu, Shu-Hao,Liu, Wei-Wei,Ruan, Xin-Chi,Shao, Zhong-Bai,Shi, Da-Hua,Su, Zi-Qin,Wang, You-Xian,Wu, Yu-Ran,Wu, Yu-Yu
, p. 281 - 286 (2021/08/05)
A series of new 1,3,4-thiadiazole Emodin amide derivatives were synthesized through the connection of 5-substituted-1,3,4-thiadiazole-2-amine and Emodin carboxylic acids which were obtained by a two-step procedure starting from Emodin. Vibrio harveyi inhibition activities of the newly prepared compounds were evaluated. Results revealed that all compounds showed different degrees of inhibition on V. harveyi. Among them, compound 7a showed the best V. harveyi inhibition effect and the minimum inhibitory concentration (MIC) was 0.0625 mg/mL.
Preparation of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles via chemoselective сyclocondensation of electrophilically activated nitroalkanes to (thio)semicarbazides or thiohydrazides
Aksenov, Alexander V.,Aksenov, Dmitrii A.,Aksenov, Nicolai A.,Arutiunov, Nikolai A.,Kirillov, Nikita K.,Rubin, Michael
, p. 1067 - 1072 (2020/10/02)
[Figure not available: see fulltext.] Unusual reaction proceeding via the electrophilic activation of nitroalkanes in the presence of polyphosphoric acid has been discovered. Subsequent nucleophilic attack with semicarbazides or thiosemicarbazides allows