400611-25-8

Basic information

• Product Name: Sulfoxonium, dimethyl-, (3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-4-phenylbutylide
• Synonyms: Sulfoxonium, dimethyl-, (3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-4-phenylbutylide;Sulfoxonium, dimethyl-, (3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-4-phenylbutylide (9CI);(3S)-3-[[(1;1-diMethylethoxy)carbonyl]aMino]-2-oxo-4-phenylbutylide (9CI);SulfoxoniuM;GZCRYTSVFLKODR-ZOWNYOTGSA-O
• CAS NO: 400611-25-8
• Molecular Formula: C₁₇H₂₅NO₄S
• Molecular Weight: 339.453
• Product Categories: API intermediates
• Mol File: 400611-25-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 163 °C
• Appearance: /
• CAS DataBase Reference: Sulfoxonium, dimethyl-, (3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-4-phenylbutylide(CAS DataBase Reference)
• NIST Chemistry Reference: Sulfoxonium, dimethyl-, (3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-4-phenylbutylide(400611-25-8)
• EPA Substance Registry System: Sulfoxonium, dimethyl-, (3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-4-phenylbutylide(400611-25-8)

Safety Data

• Hazardous Substances Data: 400611-25-8(Hazardous Substances Data)

Usage

General Description

Sulfoxonium, dimethyl-, (3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-4-phenylbutylide is a chemical compound with a complex structure. It contains a sulfoxonium group, a dimethyl group, a carbonyl amino group, and a phenylbutylide group. The compound has a chiral center with a 3S configuration. It is a derivative of dimethyl sulfoxonium and contains a carbonyl amino group attached to a 2-oxo-4-phenylbutylide moiety. Its chemical properties and potential applications are not specified in the given information.

Upstream product

• 7535-56-0 N-t-butoxycarbonyl-L-phenylalanine 4-nitrophenyl ester 
• 1774-47-6 trimethylsulfoxonium iodide 
• 1247065-58-2 C₁₈H₂₈NO₇P 
• 67729-36-6 Boc-Phe-O-COO-isoBu 
• 1247065-55-9 C₂₁H₂₃NO₆ 
• 5034-06-0 trimethyl sulfoxonium chloride 
• 1247065-56-0 C₂₂H₂₅NO₆ 
• 1247065-59-3 C₁₈H₂₁N₃O₅ 
• 34101-07-0 (2S)-2-[N-(tert-butoxycarbonyl)amino]-1-imidazol-1-yl-3-phenylpropan-1-one 
• 1247065-61-7 C₁₇H₂₁N₃O₃ 
• 1247065-60-6 C₁₈H₂₁N₃O₅ 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Downstream Products

• 102123-74-0 (S)-tert-butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate 
• 98760-08-8 (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester 
• 165727-45-7 tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate 
• 1253782-96-5 C₂₁H₂₆N₂O₃ 
• 1253782-99-8 C₂₂H₂₇NO₄ 

Relevant articles and documents

Synthesis method of (2S, 3S)-3-(t-butyloxycarboryl amino)-1, 2-epoxy-4-phenylbutane

The invention relates to the technical field of synthesis of drug intermediates, in particular to a synthesis method of (2S, 3S)-3-(t-butyloxycarboryl amino)-1, 2-epoxy-4-phenylbutane. The method comprises the following steps: condensing N-t-butyloxycarboryl-L-phenylalanine serving as a raw material with substituted phenol under the action of a condensing agent to obtain active ester 15; reacting the active ester 15 with a ylide reagent and alkali to obtain a sulfoxide ylide intermediate 16; reacting the sulfoxide ylide intermediate 16 with halide salt under the action of a catalyst to obtain a halogenated ketone intermediate 6; reducing the halogenated ketone intermediate 6 through a reducing agent under the action of a catalyst to obtain a halogenated methanol intermediate 7; and removing halogen acid from the halogenated methanol intermediate 7 under the action of alkali, and carrying out condensation cyclization to obtain the target product (2S, 3S)-3-(t-butyloxycarboryl amino)-1, 2-epoxy-4-phenylbutane. The synthesis method of the (2S, 3S)-3-(t-butyloxycarboryl amino)-1, 2-epoxy-4-phenylbutane, provided by the invention, has the characteristics of cheap and easily available initial raw materials, safe and controllable process and easiness in operation.

PROCESSES FOR THE PREPARATION OF ALPHA-CHLOROKETONES FROM CARBOXYLIC ACIDS

The present disclosure provides compositions and methods for the preparation of ? chloroketones from carboxylic acids. In particular embodiments, the present disclosure provides procedures for the preparation of chiral ? chloroketone derivatives of amino acids.