400613-92-5

Basic information

• Product Name: 2-(2-methyl-2-nitropropyl)Naphthalene
• Synonyms: 2-(2-methyl-2-nitropropyl)Naphthalene
• CAS NO: 400613-92-5
• Molecular Formula: C14H15NO2
• Molecular Weight: 229.2744
• Mol File: 400613-92-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-methyl-2-nitropropyl)Naphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-methyl-2-nitropropyl)Naphthalene(400613-92-5)
• EPA Substance Registry System: 2-(2-methyl-2-nitropropyl)Naphthalene(400613-92-5)

Safety Data

• Hazardous Substances Data: 400613-92-5(Hazardous Substances Data)

Usage

Nitroalkane

A nitro group (-NO2) attached to an alkane chain This compound contains a nitro group, which is a functional group consisting of an oxygen-nitrogen-oxygen bond, attached to an alkane chain.

Derivative of naphthalene

A polycyclic aromatic hydrocarbon 2-(2-methyl-2-nitropropyl)Naphthalene is derived from naphthalene, which is a type of polycyclic aromatic hydrocarbon (PAH) consisting of two fused benzene rings.

Potential as an explosive material

Due to the presence of the nitro group Nitro compounds are known for their explosive properties, and the presence of this group in 2-(2-methyl-2-nitropropyl)Naphthalene suggests that it may also have potential as an explosive material.

Applications in organic synthesis

The presence of the alkane chain and aromatic ring The structure of this compound, with its alkane chain and aromatic ring, indicates that it may have applications in organic synthesis or as a precursor to other chemicals.

Hazardous material

Handle with care and in accordance with safety guidelines Due to its potential explosive nature, 2-(2-methyl-2-nitropropyl)Naphthalene should be handled with caution and in compliance with safety guidelines for hazardous materials.

Upstream product

• 79-46-9 2-nitropropane 
• 2018-90-8 naphthalen-2-ylmethylamine 
• 613-46-7 2-naphthalenecarbonitrile 

Downstream Products

• 284035-33-2 NPS 2143 
• 1187330-93-3 2-chloro-6-(2-hydroxy-3-((2-methyl-1-(naphthalen-2-yl)propan-2-yl)amino)propoxy)benzonitrile 

Relevant articles and documents

Synthesis of the calcilytic ligand NPS 2143

(R)-3 (NPS 2143) is a negative allosteric modulator of the human calcium-sensing receptor (CaSR) and as such represents an important pharmacological tool compound for studying the CaSR. Herein, we disclose for the first time a complete experimental description, detailed characterisation and assessment of enantiomeric purity for (R)-3. An efficient, reproducible and scalable synthesis of (R)-3 that requires a minimum of chromatographic purification steps is presented. (R)-3 was obtained in excellent optical purity (er > 99:1) as demonstrated by chiral HPLC and the pharmacological profile for (R)-3 is in full accordance with that reported in the literature.

Calcium receptor antagonist

A compound of the formula [I] wherein R1 is optionally substituted aryl group or optionally substituted heteroaryl group; R2 is optionally substituted C1-6 alkyl group, C3-7 cycloalkyl group and the like; R3 is hydrogen atom, C1-6 alkyl group, hydroxyl group and the like; R4 is hydrogen atom, C1-6 alkyl group and the like; R5 and R6 are each C1-6 alkyl group and the like; R7 is optionally substituted aryl group or optionally substituted heteroaryl group; X1, X2 and X3 are each C1-6 alkylene group and the like; and X4 and X5 are each a single bond, methylene group and the like, a salt thereof, a solvate thereof or a prodrug thereof, and a pharmaceutical composition containing the compound, particularly a calcium receptor antagonist and a therapeutic agent for osteoporosis, are provided. The compound of the present invention is useful as a therapeutic drug of diseases accompanied by abnormal calcium homeostasis, or osteoporosis, hypoparathyreosis, osteosarcoma, periodontal disease, bone fracture, steoarthrosis, chronic rheumatoid arthritis, Paget's disease, humoral hypercalcemia, autosomal dominant hypocalcemia and the like. In addition, an intermediate for the compound is provided.