401567-11-1

Basic information

• Product Name: 2H-Benzimidazol-2-one,5-fluoro-1,3-dihydro-1-methyl-(9CI)
• Synonyms: 2H-Benzimidazol-2-one,5-fluoro-1,3-dihydro-1-methyl-(9CI)
• CAS NO: 401567-11-1
• Molecular Formula: C₈H₇FN₂O
• Molecular Weight: 166.1523832
• Product Categories: BENZIMIDAZOLE
• Mol File: 401567-11-1.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Density: 1.315±0.06 g/cm3(Predicted)
• PKA: 11.20±0.30(Predicted)
• CAS DataBase Reference: 2H-Benzimidazol-2-one,5-fluoro-1,3-dihydro-1-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Benzimidazol-2-one,5-fluoro-1,3-dihydro-1-methyl-(9CI)(401567-11-1)
• EPA Substance Registry System: 2H-Benzimidazol-2-one,5-fluoro-1,3-dihydro-1-methyl-(9CI)(401567-11-1)

Safety Data

• Hazardous Substances Data: 401567-11-1(Hazardous Substances Data)

Usage

Type

Fluorinated derivative of benzimidazol-2-one

Substitutions

5-fluoro substitution at the 1-position
1-methyl substitution at the 3-position

Structure

Heterocyclic organic molecule

Potential Pharmaceutical Applications

Biological activities related to its structural features
Interactions with enzymes or receptors in the body

Need for Further Research

To fully understand the properties and potential uses of this chemical.

Upstream product

• 401567-10-0 4-fluoro-N₁-methylbenzene-1,2-diamine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 131780-97-7 (4-Fluoro-2-nitro-phenyl)-methyl-amine 
• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 704-05-2 (4-fluoro-2-nitrophenyl)-(methyl)amine 
• 201849-15-2 2-bromo-1-chloro-4-fluoro-benzene 
• 598-50-5 N-Methylurea 

Downstream Products

• 401567-12-2 2-chloro-5-fluoro-1-methyl-1H-benzimidazole 

Relevant articles and documents

1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to 1,3,4-oxadiazole derivative compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, a use thereof in preparation of a medicament, a pharmaceutical composition comprising the same, a therapeutic method using the composition, and a method for preparing the same, and the 1,3,4-oxadiazole derivative compounds are represented by a following chemical formula (I).

1,3-dimethyl benzimidazolones are potent, selective inhibitors of the brpf1 bromodomain

The BRPF (bromodomain and PHD finger-containing) protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes. Here, we report the discovery, binding mode, and structure-activity relationship (SAR) of the firs

COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4-INHIBITORS AND EP4-RECEPTOR-ANTAGONISTS

The present invention relates to new medicament combinations which contain in addition to one or more PDE4-inhibitors (1) at least one EP4 receptor antagonist (2), as well as the use thereof for the treatment of preferably respiratory complaints such as particularly COPD, chronic sinusitis and asthma. The invention relates in particular to those medicament combinations which contain at least one EP4 receptor antagonist (2), in addition to one or more, preferably one, PDE4 inhibitor of general formula 1 wherein X is SO or SO2, but preferably SO, and wherein R3 denotes an optionally substituted, mono- or bicyclic, unsaturated, partly saturated or saturated heterocyclic group or an optionally substituted, mono- or bicyclic heteroaryland wherein R1 and R2 have the meanings given in claim 1, the preparation thereof and the use thereof for the treatment of respiratory complaints.