401894-76-6Relevant articles and documents
PHOSPHATE DERIVATIVES AND USE THEREOF
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Paragraph 0100; 0102, (2021/02/05)
The present invention discloses a compound with the following formula (I), or a tautomer, mesomer, racemate, enantiomer, and diastereoisomer thereof, or a mixture form thereof, or a pharmaceutically acceptable salt thereof, or a prodrug molecule thereof, wherein D is selected from: The invention further discloses the use of the compound in the preparation of drugs for preventing and/or treating cancers, and the use of the compound in the preparation of drugs for inhibiting cancer metastasis. The compound of the present invention can effectively inhibit the proliferation and metastasis of cancer cells by adjusting the acidity of a tumor microenvironment to achieve a better effect in clinical cancer treatment, and has broad application prospects.
Synthesis of Lower rim polyhydroxylated calix[4]arenes
Segura,Sansone,Casnati,Ungaro
, p. 2105 - 2112 (2007/10/03)
Several synthetic procedures were evaluated and a protective/deprotective method, which allows the introduction of two, three, and four amide-linked polyhydroxylated units (TRIS) at the lower rim of calix[4]arenes was developed. Di- and trifunctionalized derivatives are poorly soluble in water, whereas the solubility of calix[4]arene having four polyhydroxylated amide groups is good (6 × 10-3 M at 25 °C).