40227-54-1

Basic information

• Product Name: 4-chloro-2-methyl-1(2H)-phthalazinone
• Synonyms: 4-chloro-2-methyl-1(2H)-phthalazinone
• CAS NO: 40227-54-1
• Molecular Formula: C₉H₇ClN₂O
• Molecular Weight: 194.61768
• Mol File: 40227-54-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-chloro-2-methyl-1(2H)-phthalazinone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-methyl-1(2H)-phthalazinone(40227-54-1)
• EPA Substance Registry System: 4-chloro-2-methyl-1(2H)-phthalazinone(40227-54-1)

Safety Data

• Hazardous Substances Data: 40227-54-1(Hazardous Substances Data)

Upstream product

• 18393-54-9 2-methyl-2,3-dihydro-phthalazine-1,4-dione 
• 2257-69-4 1-chloro-4-phthalazinone 
• 77-78-1 dimethyl sulfate 
• 87878-21-5 1-(4-nitrophenyl)-3-phenyl-5-(2-methyl-4-chloro-1,2-dihydro-1-phthalazinylidene)-3-phenylformazan EE'E'' form 
• 87878-20-4 1,3-diphenyl-5-(2-methyl-4-chloro-1,2-dihydro-1-phthalazinylidene)formazan EE'E'' form 
• 85093-49-8 2-(4-nitrophenyl)-4-(2-methyl-4-chloro-1,2-dihydro-1-phthalazinylidene)benzohydrazidine 
• 74-88-4 methyl iodide 
• 87878-22-6 2-phenyl-4-(2-methyl-4-chloro-1,2-dihydro-1-phthalazinylidene)benzohydrazidine 
• 64640-64-8 2-methyl-4-chloro-1-phthalazinone hydrazone 
• 85-44-9 phthalic anhydride 

Downstream Products

• 109446-98-2 sulfanilic acid-(3-methyl-4-oxo-3,4-dihydro-phthalazin-1-ylamide) 
• 111297-94-0 N-acetyl-sulfanilic acid-(3-methyl-4-oxo-3,4-dihydro-phthalazin-1-ylamide) 

Relevant articles and documents

PHTHALAZINE DERIVATIVES OF FORMULA (I) AS PCAF AND GCN5 INHIBITORS FOR USE IN THE TREATMENT OF CANCER

The present invention relates to methods for treating PCAF and GCN5 mediated disorders using a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein ring A, R1, R3, R4, R5, and each Re have any of the values defined in the specification. Also included are novel compounds of Formula (I) and salts thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.

Study on ferrocenes, Part 6.* Synthesis and structure of ferrocenylmethylidenehydrazino-phthalazinones and -pyrido[2,3-d]pyridazinones

Hydrazinophthalazinones and -pyrido[2,3-d]pyridazinones 3a-j easily underwent a stereoselective condensation reaction with formylferrocene (1a) to give hydrazones 4a-j of E configuration. In much slower conversions acetylferrocene (1b) only condensed with hydrazinophthalazinones 3b,c yielding hydrazones 5b as a mixture of E/Z isomers and 5c purely in E form, respectively. The stereostructure of products was proved by IR, 1D- and 2D-NMR methods and for 4b,j by X-ray analysis.

AMINOPHTHALAZINONE DERIVATIVES, VII REACTION OF CHLOROPHTHALAZINONE WITH SECONDARY AMINES STUDY OF THE STERIC EFFECT, II

In the aminolysis of chlorophthalazinone (1a) with secondary amines, the yield of N-substitution (1 5, 1 7) is significantly affected by the steric structure of the amine.In the cyclic secondary amines substituents at the C-2 position give rise to a strong steric hindrance.The possibility for N-substitution gradually decreases with increasing size of the ring, while in the case of open-chain secondary amines it varies suddenly as a function of the position of the NH group in the chain.