4023-53-4 Usage
Description
TRIS(2-CYANOETHYL)PHOSPHINE, also known as TCEP, is an organophosphorus compound with the chemical formula (C6H8NP)3. It is a colorless, hygroscopic liquid that is soluble in water and organic solvents. TCEP is known for its strong reducing properties and is widely used in various chemical reactions and applications due to its ability to reduce disulfide bonds and other functional groups.
Uses
Used in Chemical Synthesis:
TRIS(2-CYANOETHYL)PHOSPHINE is used as a reducing agent for the production of 3,3',3''-phosphanetriyl-tri-propionic acid and hydrochloride by heating. It is essential in this application due to its strong reducing capabilities, which facilitate the formation of the desired product.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, TRIS(2-CYANOETHYL)PHOSPHINE is used as a reagent for the reduction of disulfide bonds in proteins and peptides. This is crucial for the proper folding and function of these biomolecules, as well as for the development of new drugs and therapies.
Used in Environmental Applications:
TRIS(2-CYANOETHYL)PHOSPHINE is employed as a reducing agent in the treatment of contaminated water and soil. Its ability to reduce harmful substances, such as heavy metals and other pollutants, makes it a valuable tool in environmental remediation efforts.
Used in Analytical Chemistry:
In analytical chemistry, TRIS(2-CYANOETHYL)PHOSPHINE is used as a reagent for the determination of various elements and compounds. Its strong reducing properties allow for the accurate measurement and analysis of target substances in complex samples.
Used in Material Science:
TRIS(2-CYANOETHYL)PHOSPHINE is utilized in the synthesis of new materials with unique properties, such as conductive polymers and advanced composites. Its ability to reduce disulfide bonds and other functional groups contributes to the development of innovative materials with potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 4023-53-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,2 and 3 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 4023-53:
(6*4)+(5*0)+(4*2)+(3*3)+(2*5)+(1*3)=54
54 % 10 = 4
So 4023-53-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H12N3P/c10-4-1-7-13(8-2-5-11)9-3-6-12/h1-3,7-9H2
4023-53-4Relevant articles and documents
Self-replication of tris(cyanoethyl)phosphine catalysed by platinum group metal complexes
Costa, Emiliana,Pringle, Paul G.,Smith, Martin B.,Worboys, Kerry
, p. 4277 - 4282 (2007/10/03)
The platinum(0) complex [Pt(tcep)3], tcep = P(CH2CH2CN)3, catalyses the formation of tcep from PH3 and CH2=CHCN. The complexes [M(tcep)3] (M = Pt, Pd or Ni) and [MCl(tcep)3] (M = Rh or Ir) are compared for their catalysis of the reaction of PH(CH2CH2CN)2 with CH2=CHCN to give tcep and it is shown that the platinum(0) complex is the most efficient. The platinum(0) catalysis has been studied in detail, monitoring the kinetics by 31P-{1H} NMR spectroscopy. It is revealed that the kinetics are a complex function of the concentration of product tcep. Qualitatively, the rates also depend on [CH2=CHCN] and [catalyst]. Both 31P-{1H} and 195Pt-{1H} NMR spectroscopy suggests that addition of CH2=CHCN to [Pt(tcep)3] gives the complex [Pt(tcep)2(η2-CH2=CHCN)] which undergoes phosphine exchange on the NMR time-scale. The binuclear complex [Pt2H2(tcep)2{η-P(CH2CH 2CN)2}2], formed upon addition of PH(CH2CH2CN)2 to trans-[PtHCl(tcep)2] in the presence of base, is shown to be a catalyst precursor for the reaction of PH(CH2CH2CN)2 with CH2=CHCN. Two parallel mechanisms involving mononuclear and binuclear intermediates are discussed to rationalise these observations.
Alkylation of phosphine PH3 generated from red phosphorus
Semenzin, Delphine,Etemad-Moghadam, Guita,Albouy, Dominique,Koenig, Max
, p. 3297 - 3300 (2007/10/02)
The generation of phosphine PH3 by alkaline hydrolysis of red phosphorus is realized. The subsequent alkylation of PH3 by terminal alkenes and alkynes in basic media leading to the corresponding aliphatic and vinylic phosphine derivatives can occur by two-steps or one-pot reaction by a Michael-like reaction mechanism.