40230-24-8Relevant articles and documents
Synthesis and biological evaluation of novel imidazopyrimidin-3-amines as anticancer agents
Mahdavi, Mohammad,Dianat, Shima,Khavari, Behnaz,Moghimi, Setareh,Abdollahi, Mohammad,Safavi, Maliheh,Mouradzadegun, Arash,Kabudanian Ardestani, Sussan,Sabourian, Reyhaneh,Emami, Saeed,Akbarzadeh, Tahmineh,Shafiee, Abbas,Foroumadi, Alireza
, p. 797 - 805 (2017)
Groebke–Blackburn–Bienayme reaction has been utilized for the synthesis of new imidazo[1,2-a]pyrimidine derivatives as novel anticancer agents. The cytotoxic activities of compounds were evaluated against human cancer cell lines including MCF-7, T-47D, an
Synthesis and characterization of antitubercular triazine-chalcone hybrid molecules
Rawat, Aman,Kaur, Atinder,Surjit,Kaur, Harpreet
, p. 2084 - 2090 (2017)
A new series of 1,3,5-triazine-chalcone hybrid molecules have been synthesized and evaluated in vitro for Mycobacterium tuberculosis H37Rv inhibitory potency using Alamar blue assay and the activity expressed as the minimum inhibitory concentration (MIC)
Iron-Catalyzed Alkyne-Based Multicomponent Synthesis of Pyrimidines under Air
Chakraborty, Gargi,Guin, Amit Kumar,Mondal, Rakesh,Paul, Nanda D.,Sarkar, Susmita
, p. 13186 - 13197 (2021/10/01)
An iron-catalyzed sustainable, economically affordable, and eco-friendly synthetic protocol for the construction of various trisubstituted pyrimidines is described. A wide range of trisubstituted pyrimidines were prepared using a well-defined, easy to prepare, bench-stable, and phosphine-free iron catalyst featuring a redox-noninnocent tridentate arylazo pincer under comparatively mild aerobic conditions via dehydrogenative functionalization of alcohols with alkynes and amidines.
A green approach for the synthesis of benzazolyl pyrimidinyl carbamothioates under ultrasonication and their antimicrobial activity
Kayathi, Narendra Babu,Panga, Siva Sankar,Adivireddy, Padmaja,Venkatapuram, Padmavathi
, p. 2931 - 2943 (2021/07/26)
A library of benzazolyl pyrimidinyl carbamothioates were prepared by the reaction of benzazolyl carbonothioates with pyrimidinyl-2-amine in the presence of an ionic liquid- 1-butyl-3-methylimidazolium hydroxide ([bmim]OH) under ultrasonication at a frequency of 35?kHz and tested for antimicrobial activity. Chloro- and nitro-substituted benzothiazolyl/benzimidazolyl pyrimidinyl carbamothioates displayed prominent antibacterial activity against Bacillus subtilis, while nitro-substituted benzothiazolyl/benzimidazolyl pyrimidinyl carbamothioates showed excellent antifungal activity against Aspergilus niger. Graphic abstract: [Figure not available: see fulltext.].