402598-52-1Relevant articles and documents
Total Synthesis and Biological Assessment of Novel Albicidins Discovered by Mass Spectrometric Networking
von Eckardstein, Leonard,Petras, Daniel,Dang, Tam,Cociancich, Stéphane,Sabri, Souhir,Gr?tz, Stefan,Kerwat, Dennis,Seidel, Maria,Pesic, Alexander,Dorrestein, Pieter C.,Royer, Monique,Weston, John B.,Süssmuth, Roderich D.
, p. 15316 - 15321 (2017)
Natural products represent an important source of potential novel antimicrobial drug leads. Low production by microorganisms in cell culture often delays the structural elucidation or even prevents a timely discovery. Starting from the anti-Gram-negative antibacterial compound albicidin produced by Xanthomonas albilineans, we describe a bioactivity-guided approach combined with non-targeted tandem mass spectrometry and spectral (molecular) networking for the discovery of novel antimicrobial compounds. We report eight new natural albicidin derivatives, four of which bear a β-methoxy cyanoalanine or β-methoxy asparagine as the central α-amino acid. We present the total synthesis of these albicidins, which facilitated the unambiguous determination of the (2 S,3 R)-stereoconfiguration which is complemented by the assessment of the stereochemistry on antibacterial activity.
Alpha-methylcinnamic acid ester derivative and liquid crystal composition
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, (2008/06/13)
Disclosed is an α-methylcinnamic acid ester derivative represented by the formula: STR1 wherein n is an integer of from 5 to 18, R1 represents an optically active group of the formula STR2 in which m is an integer of from 1 to 5 and *C represen
