4026-97-5 Usage
Description
(3beta,5beta,8xi,9xi,15beta,16beta)-3,16-bis(acetyloxy)-14,15-epoxybufa-20,22-dienolide is a complex chemical compound belonging to the bufadienolides class, which are cardiac glycosides found in the venom of specific toad species. (3beta,5beta,8xi,9xi,15beta,16beta)-3,16-bis(acetyloxy)-14,15-epoxybufa-20,22-dienolide is distinguished by its unique structure, featuring acetyl groups at the 3rd and 16th positions and an epoxy group between the 14th and 15th positions on the bufadienolide backbone. These structural elements are crucial for its biological activities and potential applications in various fields, including anticancer, antimicrobial, and cardiovascular therapies.
Uses
Used in Pharmaceutical Industry:
(3beta,5beta,8xi,9xi,15beta,16beta)-3,16-bis(acetyloxy)-14,15-epoxybufa-20,22-dienolide is utilized as a potential anticancer agent due to its ability to target and inhibit the growth of cancer cells. Its unique structure allows for specific interactions with cellular components, making it a promising candidate for the development of novel cancer treatments.
Used in Antimicrobial Applications:
In the field of antimicrobial research, (3beta,5beta,8xi,9xi,15beta,16beta)-3,16-bis(acetyloxy)-14,15-epoxybufa-20,22-dienolide is employed for its potential to combat various microorganisms, including bacteria and fungi. Its structural features enable it to disrupt essential cellular processes in these pathogens, offering a new avenue for the development of antimicrobial agents.
Used in Cardiovascular Research:
(3beta,5beta,8xi,9xi,15beta,16beta)-3,16-bis(acetyloxy)-14,15-epoxybufa-20,22-dienolide is also used in cardiovascular research as a potential agent for the treatment of heart diseases. Its cardiac glycoside nature suggests that it may have beneficial effects on heart function and could be instrumental in the development of new therapies for cardiovascular conditions.
Overall, the diverse pharmacological properties and complex structure of (3beta,5beta,8xi,9xi,15beta,16beta)-3,16-bis(acetyloxy)-14,15-epoxybufa-20,22-dienolide make it a subject of significant interest for further research and potential drug development across multiple medical fields.
Check Digit Verification of cas no
The CAS Registry Mumber 4026-97-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,2 and 6 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4026-97:
(6*4)+(5*0)+(4*2)+(3*6)+(2*9)+(1*7)=75
75 % 10 = 5
So 4026-97-5 is a valid CAS Registry Number.
4026-97-5Relevant articles and documents
Microbial transformation of three bufadienolides by Nocardia sp. and some insight for the cytotoxic structure-activity relationship (SAR)
Zhang, Jian,Sun, Yang,Liu, Ji-Hua,Yu, Bo-Yang,Xu, Qiang
, p. 6062 - 6065 (2008/09/16)
Resibufogenin, cinobufagin, and bufalin are cytotoxic steroids isolated from the Chinese drug Chan'su. Biotransformation of these three bufadienolides by Nocardia sp. NRRL 5646 was investigated. Notably, resibufogenin was converted to 3-acetyl 15β-hydroxyl bufotalin, via an unprecedented 14β,15β-epoxy ring cleavage and a regio-selective acetoxylation. This product showed significantly increased cytotoxic activity. The regio-selective acetylation of the 3-OH was also involved in the other reactions. The structures of metabolites were established by ESI-LC/MS and 2D NMR techniques. The in vitro cytotoxic activities against human cancer cell lines of the substrates and the transformed products were determined by the MTT method and their structure-activity relationship (SAR) was discussed. This investigation provided a useful approach to prepare new bufadienolides and the SAR research.
