40358-49-4

Basic information

• Product Name: 3-Furanmethanol, a-phenyl-
• CAS NO: 40358-49-4
• Molecular Formula: C11H10O2
• Molecular Weight: 174.199
• Mol File: 40358-49-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-Furanmethanol, a-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Furanmethanol, a-phenyl-(40358-49-4)
• EPA Substance Registry System: 3-Furanmethanol, a-phenyl-(40358-49-4)

Safety Data

• Hazardous Substances Data: 40358-49-4(Hazardous Substances Data)

Upstream product

• 498-60-2 furan-3-carboxaldehyde 
• 108-86-1 bromobenzene 
• 591-51-5 phenyllithium 
• 100-58-3 phenylmagnesium bromide 
• 117305-67-6 6-phenyl-2,7-dioxabicyclo[3.2.0]hept-3-ene 

Downstream Products

• 1016926-23-0 2-phenyl-furan-3-carboxaldehyde 
• 136131-55-0 2-benzyl-8-phenyl-1-naphthol 
• 136131-56-1 2-benzyl-8-carbomethoxy-1-naphthol 
• 136131-54-9 2-benzyl-8-methyl-1-naphthol 
• 136131-41-4 2-benzyl-1,4-dihydro-1,4-epoxynaphthalene 
• 123239-69-0 3-benzyl-1-naphthol 
• 36441-32-4 2-benzyl-1-naphthol 
• 62495-31-2 3-(phenylmethyl)furan 

Relevant articles and documents

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Oxidation of 3-furfurylcarbinols with bromine in acetone-water

Oxidation of 3-furfurylcarbinols 3a-e and 7 with bromine in acetone-water solution gave the 2-substituted-3-furfurals 4a-e and 8 in good yields, respectively. Reaction of 2-alkyl-3-furfurylcarbinols 9a and 9b with bromine in acetone-water gave the bromoal

Design, synthesis, and structure-activity relationships of pyrazolo[3,4-d]pyrimidines: A novel class of potent enterovirus inhibitors

A series of pyrazolo[3,4-d]pyrimidines were synthesized and their antiviral activity was evaluated in a plaque reduction assay. It is very interesting that this class of compounds provide remarkable evidence that they are very specific for human enteroviruses, in particular, coxsackieviruses. Some derivatives proved to be highly effective in inhibiting enterovirus replication at nanomolar concentrations. SAR studies revealed that the phenyl group at the N-1 position and the hydrophobic diarylmethyl group at the piperazine largely influenced the in vitro antienteroviral activity of this new class of potent antiviral agents. It was found that the pyrazolo[3,4-d]pyrimidines with a thiophene substituent, such as compounds 20-24, in general exhibited high activity against coxsackievirus B3 (IC50=0.063-0.089μM) and moderate activity against enterovirus 71 (IC50=0.32-0.65μM) with no apparent cytotoxic effect toward RD (rhabdomyosarcoma) cell lines (CC5025μ M).