403656-89-3 Usage
Description
Fulvestrant 17-Ketone is an impurity derived from Fulvestrant (F862500), a steroidal estrogen antagonist that is devoid of any partial agonist activity. It is characterized by its antineoplastic properties, particularly in the context of hormonal therapies.
Uses
Used in Pharmaceutical Industry:
Fulvestrant 17-Ketone is used as an impurity in the production of Fulvestrant, an antineoplastic hormone therapy agent. It plays a role in the development and formulation of medications targeting hormone-responsive cancers, such as breast cancer, by potentially enhancing the effectiveness or stability of the primary therapeutic compound, Fulvestrant.
Used in Anticancer Applications:
Although primarily known as an impurity, Fulvestrant 17-Ketone may also be investigated for its own potential anticancer properties. As a derivative of a steroidal estrogen antagonist, it could be studied for its impact on tumor growth and progression in hormone-responsive cancers, possibly leading to novel treatment strategies or drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 403656-89-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,3,6,5 and 6 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 403656-89:
(8*4)+(7*0)+(6*3)+(5*6)+(4*5)+(3*6)+(2*8)+(1*9)=143
143 % 10 = 3
So 403656-89-3 is a valid CAS Registry Number.
403656-89-3Relevant articles and documents
Putative metabolites of fulvestrant, an estrogen receptor downregulator. Improved glucuronidation using trichloroacetimidates
Ferguson,Harding,Killick,Lumbard,Scheinmann,Stachulski
, p. 3037 - 3041 (2001)
Following regioselective protection of the estrogen receptor downregulator fulvestrant (ICI 182,780) 1 as its 17-acetate 2 or 3-benzoate 4, the 3-sulfate 5 and 3- and 17-glucuronide conjugates 8 and 12 were prepared. Satisfactory preparation of 12 required use of the tri-O-isobutyryl imidate derivative 10 in conjunction with an inverse-addition technique not previously employed in glucuronidation. The value of this method for simpler aglycones is discussed together with a study of variations in donor acyl substituent and catalyst. Another putative metabolite, the 17-ketone 19, was prepared by direct oxidation of 1.
