40372-03-0 Usage
Description
Ribavirin 2',3',5'-triacetate is a modified form of the antiviral drug ribavirin, which is a purine nucleoside analog. It is characterized by the presence of three acetyl groups attached to the 2', 3', and 5' positions of the ribavirin molecule. This modification enhances the stability and bioavailability of the drug, making it more suitable for various applications.
Uses
Used in Antiviral Applications:
Ribavirin 2',3',5'-triacetate is used as an antiviral agent for the treatment of various viral infections. It works by inhibiting the inosine monophosphate dehydrogenase (IMPDH) enzyme, which is essential for the synthesis of guanosine nucleotides required for viral replication. This inhibition leads to a reduction in the viral load and helps in controlling the spread of the infection.
Used in Pyruvate Dehydrogenase (PDH) Related Research:
Ribavirin 2',3',5'-triacetate is also used in research related to pyruvate dehydrogenase (PDH), an enzyme complex that plays a crucial role in cellular metabolism. ribavirin 2',3',5'-triacetate can be employed to study the effects of PDH inhibition on cellular processes and to develop new therapeutic strategies for conditions related to PDH dysfunction.
Check Digit Verification of cas no
The CAS Registry Mumber 40372-03-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,3,7 and 2 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 40372-03:
(7*4)+(6*0)+(5*3)+(4*7)+(3*2)+(2*0)+(1*3)=80
80 % 10 = 0
So 40372-03-0 is a valid CAS Registry Number.
InChI:InChI=1/C14H18N4O8/c1-6(19)23-4-9-10(24-7(2)20)11(25-8(3)21)14(26-9)18-5-16-13(17-18)12(15)22/h5,9-11,14H,4H2,1-3H3,(H2,15,22)/t9-,10-,11-,14-/m1/s1
40372-03-0Relevant articles and documents
Oligomer conjugates of heteropentacyclic nucleosides
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Page/Page column 35; 36; 37, (2015/12/09)
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer.
Synthesis and antitumor activity of ribavirin imidates. A new facile synthesis of ribavirin amidine (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine hydrochloride)
Kini,Robins,Avery
, p. 1447 - 1449 (2007/10/02)
Methyl 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboximidate (4) and ethyl 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboximidate (6) were synthesized and tested for antitumor and antiviral activity. A new facile synthesis of 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine hydrochloride (5), starting with imidate 4, was also developed. The imidates 4 and 6 differed greatly in solubility and dosing requirements. Even so, both compounds exhibited significant activity in vivo against murine leukemia L1210. Nontoxic dosing with 4 also significantly diminished Friend leukemia induced splenomegaly. In contrast, neither imidate was active in vitro.
