403985-96-6

Basic information

• Product Name: (S)-1-(triphenylmethoxy)-3-buten-2-ol
• Synonyms: (S)-1-(triphenylmethoxy)-3-buten-2-ol
• CAS NO: 403985-96-6
• Molecular Formula: C₂₃H₂₂O₂
• Molecular Weight: 330.41958
• Mol File: 403985-96-6.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-1-(triphenylmethoxy)-3-buten-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(triphenylmethoxy)-3-buten-2-ol(403985-96-6)
• EPA Substance Registry System: (S)-1-(triphenylmethoxy)-3-buten-2-ol(403985-96-6)

Safety Data

• Hazardous Substances Data: 403985-96-6(Hazardous Substances Data)

Usage

Description

(S)-1-(triphenylmethoxy)-3-buten-2-ol is a chemical compound that belongs to the class of allyl alcohols. It is an asymmetric molecule with one chiral center, which means it exists in two enantiomeric forms. (S)-1-(triphenylmethoxy)-3-buten-2-ol is not commonly found in nature and is mostly synthesized in the laboratory for research purposes. Its unique structure and reactivity make it a valuable building block for the preparation of complex organic molecules.

Uses

Used in Pharmaceutical Industry:
(S)-1-(triphenylmethoxy)-3-buten-2-ol is used as an intermediate in the synthesis of pharmaceuticals due to its versatile nature and ability to be used in the production of various drugs.
Used in Agrochemical Industry:
(S)-1-(triphenylmethoxy)-3-buten-2-ol is used as a building block in the development of agrochemicals, contributing to the creation of effective and targeted products for agricultural applications.
Used in Fine Chemicals Industry:
(S)-1-(triphenylmethoxy)-3-buten-2-ol is used as a versatile intermediate in the production of fine chemicals, where its unique structure and reactivity are harnessed to create high-quality specialty products.
Used in Material Development:
(S)-1-(triphenylmethoxy)-3-buten-2-ol has potential applications in the development of new materials, where its unique properties can be utilized to create innovative and improved materials for various industries.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
(S)-1-(triphenylmethoxy)-3-buten-2-ol is used as a chiral auxiliary in asymmetric synthesis, playing a crucial role in the production of enantiomerically pure compounds, which are essential in various chemical and pharmaceutical applications.

Upstream product

• 2181-42-2 trimethylsulphonium iodide 
• 129940-50-7 (S)-tritylglycidol 
• 949583-79-3 (E)-methyl (4-(trityloxy)but-2-en-1-yl)carbonate 
• 76-83-5 trityl chloride 
• 62214-39-5 (2S)-but-3-ene-1,2-diol 

Downstream Products

• 403985-94-4 C₂₆H₂₆O₂ 
• 863012-09-3 (2S,6S)-2-Benzyloxy-6-trityloxymethyl-3,6-dihydro-[1,2]oxaphosphinine 2-oxide 
• 863012-15-1 (2S,5R,6R)-2-Benzyloxy-2-oxo-6-trityloxymethyl-5,6-dihydro-2H-2λ⁵-[1,2]oxaphosphinin-5-ol 
• 863012-10-6 (2S,5S,6R)-2-Benzyloxy-2-oxo-6-trityloxymethyl-5,6-dihydro-2H-2λ⁵-[1,2]oxaphosphinin-5-ol 
• 863012-07-1 (S)-Allyl-phosphonic acid benzyl ester (S)-1-trityloxymethyl-allyl ester 
• 863012-08-2 (2S,4R,5S,6R)-2-phenylmethoxy-6-[(triphenylmethoxy)methyl]-1,2-oxaphosphorinane-4,5-diol 2-oxide 
• 863012-13-9 Methanesulfonic acid (2S,5S,6R)-2-benzyloxy-2-oxo-6-trityloxymethyl-5,6-dihydro-2H-2λ⁵-[1,2]oxaphosphinin-5-yl ester 
• 863012-11-7 (2S,3S,4R,5S,6R)-2-Benzyloxy-2-oxo-6-trityloxymethyl-2λ⁵-[1,2]oxaphosphinane-3,4,5-triol 
• 863012-14-0 Benzoic acid (2S,5R,6R)-2-benzyloxy-2-oxo-6-trityloxymethyl-5,6-dihydro-2H-2λ⁵-[1,2]oxaphosphinin-5-yl ester 
• 403985-91-1 (S)-2-trityloxymethyl-2,5-dihydrofuran 
• 602326-53-4 (2S,3R,4R)-3,4-epoxy-2-trityloxymethyl-tetrahydrofuran 
• 602326-51-2 (2R,3S,4S)-3,4-epoxy-2-trityloxymethyl-tetrahydrofuran 
• 602326-54-5 1,4-anhydro-2-azido-2-deoxy-5-O-trityl-D-arabino-pentitol 
• 1174321-91-5 ethyl ((S)-1-trityloxymethylallyloxy)acetate 

Relevant articles and documents

Efficient Method for the Synthesis of Amino-1,3-Oxazines from Thioureas

The synthesis of a subtype-selective inhibitor BACE-1 inhibitor is presented. One of the key transformations in this sequence is the conversion of a thiourea to the bicyclic 1,3-aminooxazine. This article outlines the development and application of this method to the target molecule as well as further exploration of its scope and mechanism.

COMBINATION THERAPY OF BACE-1 INHIBITOR AND ANTI-N3PGLU ABETA ANTIBODY

The present invention provides a method of treating a cognitive or neurodegenerative disease, comprising administering to a patient in need of such treatment an effective amount of a compound of the formula or a pharmaceutically acceptable salt thereof in combination with an effective amount of an anti-N3pGlu Abeta antibody selected from the group consisting of hE8L, B12L, R17L, Antibody I, and Antibody II.

N-[3-[2-AMINO-5-(1,1-DIFLUOROETHYL)-4,4A,5,7-TETRAHYDROFURO[3,4-D][1,3]OXAZIN-7A-YL]-4-FLUORO-PHENYL]-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXAMIDE AND ITS (4AR,5S,7AS) ISOMER AS A SELECTIVE BACE1 INHIBITOR FOR TREATING E.G. ALZHEIMER'S DISEASE

The present invention provides N-[3-[2-Amino-5-(1,1-difluoroethyl) -4,4a,5,7-tetrahydrofuro[3,4-d][1,3]oxazin-7a-yl]-4-fluoro-phenyl]-5- (trifluoromethyl)pyridine-2-carboxamide, i.e. the compound of Formula I: [Formula should be inserted here] or a pharma