404-15-9

Basic information

• Product Name: 1-ACETOXY-4-FLUOROBENZENE
• Synonyms: ACETIC ACID 4-FLUOROPHENYL ESTER;P-FLUOROPHENYL ACETATE;fluoro-aceticaciphenylester;phenylfluoroacetate
• CAS NO: 404-15-9
• Molecular Formula: C₈H₇FO₂
• Molecular Weight: 154.14
• EINECS: 206-972-4
• Product Categories: Aromatic Halides (substituted)
• Mol File: 404-15-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 197 °C(lit.)
• Flash Point: 190 °F
• Appearance: /
• Density: 1.178 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.432mmHg at 25°C
• Refractive Index: n20/D 1.48(lit.)
• CAS DataBase Reference: 1-ACETOXY-4-FLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ACETOXY-4-FLUOROBENZENE(404-15-9)
• EPA Substance Registry System: 1-ACETOXY-4-FLUOROBENZENE(404-15-9)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 404-15-9(Hazardous Substances Data)

Usage

General Description

1-Acetoxy-4-fluorobenzene is a chemical compound with the molecular formula C8H7FO2. It is an aromatic organic compound with a benzene ring substituted by a fluorine atom and an acetoxy group. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is a colorless liquid with a strong aromatic odor and is insoluble in water but soluble in organic solvents. 1-Acetoxy-4-fluorobenzene is also known by other names such as p-Fluoroacetophenone and 1-Acetyl-4-fluorobenzene. It is important to handle and use this chemical with caution, as it can be harmful if inhaled, ingested, or comes into contact with the skin.

InChI:InChI=1/C8H7FO2/c1-6(10)11-8-4-2-7(9)3-5-8/h2-5H,1H3

Upstream product

• 359-06-8 monofluoroacetyl chloride 
• 108-95-2 phenol 
• 450-95-3 2-fluoroacetophenone 

Relevant articles and documents

A new finding in selective Baeyer-Villiger oxidation of α-fluorinated ketones; a new and practical route for the synthesis of α-fluorinated esters

α-Fluorinated esters were effectively prepared by the Baeyer-Villiger oxidation of α-fluorinated ketones with m-chloroperbenzoic acid (m-CPBA) under mild conditions. The yield of the esters was influenced by the choice of solvent, base, and substituent on the aryl group of the ketones. 4-Methoxyphenyl substituted fluoroketones were oxidized almost quantitatively with m-CPBA within 10 min to 12 h at room temperature using 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as a cosolvent with CH2Cl2 (1:1, v/v) and aqueous buffer (KH2PO4-NaOH, pH 7.6) as an additive base. The oxidation reaction rates of α-fluorinated ketones were higher than those of the corresponding non-fluorinated ketones. The fluorine atom at α-position of fluoromethyl aryl ketones enhanced the reactivity in the Baeyer-Villiger oxidation.