404942-59-2Relevant articles and documents
Eluent tolerance and enantioseparation recovery of chiral packing materials based on chitosan bis(phenylcarbamate)-(n-octyl urea)s for high performance liquid chromatography
Wang, Jing,Huang, Shao-Hua,Chen, Wei,Bai, Zheng-Wu
supporting information, (2016/12/02)
The goal of the present work was to study the influence of the swelling of chitosan derivatives on the enantioseparation and the separation performance recovery of chiral stationary phases (CSPs) based on these derivatives. Therefore, six chitosan bis(phenylcarbamate)-(n-octyl urea)s were synthesized, which were coated on macroporous 3-aminopropyl silica gel affording new CSPs. Most of the CSPs demonstrated strong enantioseparation capability for the tested chiral compounds. The swelling capacity of the chitosan bis(phenylcarbamate)-(n-octyl urea)s in ethyl acetate, acetone and tetrahydrofuran (THF) was evaluated. Among the chitosan derivatives, the chitosan bis(3,5-dichlorophenylcarbamate)-(n-octyl urea) polymer showed the highest swelling capacity in ethyl acetate and THF. The polymer-based CSPs could be utilized with pure ethyl acetate and a normal phase containing 70% THF, but was damaged by pure THF. On the other hand, the separation performance of the damaged CSP could be recovered after it was allowed to stand for a period of time. The observations are important for the development and application of polysaccharide derivative-based CSPs.
Chiral self-discrimination of the enantiomers of α-phenylethylamine derivatives in proton NMR
Huang, Shao-Hua,Bai, Zheng-Wu,Feng, Ji-Wen
experimental part, p. 423 - 427 (2010/04/05)
Two types of chiral analytes, the urea and amide derivatives of α-phenylethylamine, were prepared. The effect of inter- molecular hydrogen-bonding interaction on self-discrimination of the enantiomers of analytes has been investigated using high-resolutio
3-Acyl-2-(N-cyanoimino)oxazolidine derivative, a new asymmetric acylating agent for racemic secondary alkyl amines
Maezaki, Naoyoshi,Furusawa, Akemi,Uchida, Shuji,Tanaka, Tetsuaki
, p. 9309 - 9315 (2007/10/03)
A 3-acyl-2-(N-cyanoimino)oxazolidine derivative was found to serve as an enantioselective acylating agent for sec-alkyl amines. These reagents differentiate the enantiomers of 1-phenylethylamine derivatives up to 85% ee, and the recovered chiral auxiliary is reusable.