40503-90-0

Basic information

• Product Name: 4-(4-Methylphenyl)cyclohexanone
• Synonyms: 4-(4-Methylphenyl)cyclohexanone;4-(4-Methylphenyl)cyclohexan-1-one;4-p-tolyl cyclohexanone;4-(p-Tolyl)cyclohexanone
• CAS NO: 40503-90-0
• Molecular Formula: C₁₃H₁₆O
• Molecular Weight: 188.268
• Mol File: 40503-90-0.mol
• Article Data: 13

Chemical Properties

• Melting Point: 49.0 to 53.0 °C
• Boiling Point: 313.851°C at 760 mmHg
• Flash Point: 133.339°C
• Appearance: /
• Density: 1.026
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 4-(4-Methylphenyl)cyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Methylphenyl)cyclohexanone(40503-90-0)
• EPA Substance Registry System: 4-(4-Methylphenyl)cyclohexanone(40503-90-0)

Safety Data

• Hazardous Substances Data: 40503-90-0(Hazardous Substances Data)

Usage

General Description

4-(4-Methylphenyl)cyclohexanone, also known as p-tolylcyclohexanone, is a chemical compound with the molecular formula C13H16O. It is a cyclic ketone that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. The compound is a white to light yellow solid with a sweet, minty odor. It is often used as a building block in the manufacture of various organic compounds due to its reactivity and versatility. Additionally, it is known for its ability to undergo various chemical transformations, making it a valuable tool in organic synthesis and research. Overall, 4-(4-Methylphenyl)cyclohexanone is an important chemical with a wide range of applications in the field of organic chemistry.

InChI:InChI=1/C13H16O/c1-10-2-4-11(5-3-10)12-6-8-13(14)9-7-12/h2-5,12H,6-9H2,1H3

Upstream product

• 36716-70-8 4-hydroxy-4-(p-tolyl)cyclohexan-1-one 
• 174911-69-4 8-p-tolyl-1,4-dioxa-spiro[4.5]decane 
• 365553-55-5 8-(4-methyl-phenyl)-1,4-dioxaspiro[4.5]dec-7-ene 
• 365553-53-3 8-(p-tolyl)-1,4-dioxaspiro[4.5]decan-8-ol 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 36716-74-2 4'-methyl-2,5-dihydro-[1,1'-biphenyl]-4(3H)-one 
• 106-38-7 para-bromotoluene 
• 170011-47-9 1,4-dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate 
• 680596-79-6 4,4,5,5-tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane 
• 5720-05-8 4-methylphenylboronic acid 
• 146631-00-7 [4-(benzyloxy)phenyl]boronic acid 
• 6793-92-6 p-benzyloxyphenylbromide 

Downstream Products

• 868142-01-2 8-p-tolyl-1,3-diaza-spiro[4.5]decane-2,4-dione 
• 868142-26-1 2,4-dioxo-8-p-tolyl-1,3-diaza-spiro[4.5]decane-1,3-dicarboxylic acid di-tert-butyl ester 
• 1297474-41-9 C₁₆H₁₄N₂OS 
• 1297474-52-2 C₂₀H₁₄N₂O₂S 
• 1297474-17-9 C₂₀H₁₆N₂O₃S 
• 1297474-32-8 C₁₆H₁₈N₂OS 
• 1393641-15-0 ethyl cis-2-diazo-2-(1-hydroxy-4-(4-methylphenyl)cyclohexyl)acetate 
• 1393641-24-1 (S)-4-(4-methylphenyl)cycloheptan-1-one 
• 1402080-46-9 5-(p-tolyl)oxepan-2-one 

Relevant articles and documents

Preparation method of trans-ketone intermediate

The invention discloses a preparation method of trans-ketone intermediates. The trans-ketone intermediates comprise compounds as shown in a formula (I) and a formula (II). The preparation process comprises the following steps: (1) performing catalytic hydrogenation on the compounds as shown in the formula (I) to prepare ketone intermediate products; (2) preparing a Grignard reagent from benzyloxy halogenated benzene and magnesium powder, and performing acidolysis dehydration on the Grignard reagent and the ketone intermediate product prepared in the step (1) to obtain a compound as shown in a formula (II); and (3) carrying out catalytic hydrogenation and isomerization reaction on the compound as shown in the formula (II) prepared in the step (2). According to the preparation method provided by the invention, the technical problem that multiple benzyl alcohol impurities and impurity products after ketone condensation exist in acidolysis dehydration products of dicyclohexanone ethylene monoketal adopted in a traditional process is solved, and the purification difficulty of trans-ketone intermediate products is greatly reduced.

NOVEL 5 or 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS SELECTIVE INHIBITORS OF INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES

Disclosed herein are 5 or 8-substituted imidazo [1, 5-a] pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo [1, 5-a] pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo [1, 5-a] pyridines that can be useful for inhibiting indoleamine 2, 3-dioxygenase and/or tryptophane 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.

Optimization of TRPV6 calcium channel inhibitors using a 3D ligand-based virtual screening method

Herein, we report the discovery of the first potent and selective inhibitor of TRPV6, a calcium channel overexpressed in breast and prostate cancer, and its use to test the effect of blocking TRPV6-mediated Ca2+-influx on cell growth. The inhib