405065-66-9

Basic information

• Product Name: 3-Butyn-2-one,4-(4-fluorophenyl)-(9CI)
• Synonyms: 3-Butyn-2-one,4-(4-fluorophenyl)-(9CI)
• CAS NO: 405065-66-9
• Molecular Formula: C₁₀H₇FO
• Molecular Weight: 162.1603832
• Product Categories: HALIDE
• Mol File: 405065-66-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Butyn-2-one,4-(4-fluorophenyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Butyn-2-one,4-(4-fluorophenyl)-(9CI)(405065-66-9)
• EPA Substance Registry System: 3-Butyn-2-one,4-(4-fluorophenyl)-(9CI)(405065-66-9)

Safety Data

• Hazardous Substances Data: 405065-66-9(Hazardous Substances Data)

Upstream product

• 766-98-3 1-ethynyl-4-fluorobenzene 
• 78191-00-1 N-Methoxy-N-methylacetamide 
• 18871-66-4 N,N-dimethylacetamide dimethyl acetal 
• 108-24-7 acetic anhydride 
• 768-60-5 4-methoxyphenylacetylen 
• 229015-32-1 (+/-)-4-(4-fluorophenyl)but-3-yn-2-ol 
• 352-34-1 4-fluoro-1-iodobenzene 

Downstream Products

• 229015-32-1 (+/-)-4-(4-fluorophenyl)but-3-yn-2-ol 
• 229015-35-4 (S)-4-(4-fluorophenyl)-3-butyn-2-ol 
• 229015-35-4 (R)-4-(4-fluorophenyl)-3-butyn-2-ol 
• 681432-59-7 1-[2-(4-fluorophenyl)pyrazolo[1,5-b]pyridazin-3-yl]ethanone 
• 681432-87-1 1-[2-(4-fluorophenyl)-6-methylpyrazolo[1,5-b]pyridazin-3-yl]ethanone 
• 681432-58-6 (2E)-3-(dimethylamino)-1-[2-(4-fluorophenyl)pyrazolo[1,5-b]pyridazin-3-yl]-2-propen-1-one 
• 681432-86-0 (2E)-3-(dimethylamino)-1-[2-(4-fluorophenyl)-6-methylpyrazolo[1,5-b]pyridazin-3-yl]-2-propen-1-one 
• 1016984-16-9 3-(4-Fluorophenyl)-1-methyl-1-phenyl-1H-indene 
• 1454790-34-1 (E)-3-(4-fluorobenzylidene)-1'-(methoxymethyl)-2',4-dioxospiro[cyclopentane-1,3'-indoline]-2,2-dicarbonitrile 
• 1612772-45-8 (E)-5-(4-bromophenyl)-2-(4-fluorobenzylidene)spiro[cyclopentane-1,2'-indene]-1',3,3'-trione 

Relevant articles and documents

Synthesis of Highly Substituted Biaryls by the Construction of a Benzene Ring via in Situ Formed Acetals

Herein, we present an interesting method for the construction of a benzene ring using propargylic alcohols and 1,3-dicarbonyls, which involves three new C-C bond formations via cascade alkylation, formylation, annulation, and aromatization to make substituted biaryls. This one-pot Br?nsted acid-promoted protocol utilizes the unique reactivity of the acetal formed under the reaction conditions. Alkynyl methyl ketones could be employed instead of 1,3-dicarbonyls as they are converted to 1,3-dicarbonyls by hydration under the reaction conditions.

Aerobic oxidation of propargylic alcohols to αβ,-unsaturated alkynals or alkynones catalyzed by fe(NOH, TEMPO and sodium chloride in toluene

A practical aerobic oxidation of propargylic alcohols using Fe(NOH, TEMPO and sodium chloride in toluene at room temperature was applied to various type of propargylic alcohols affording ,-unsaturated alkynals or alkynones in good to excellent yields. This protocol could be applied in academic laboratories as well as in industrial-scale production.

Convenient synthesis of arylpropargyl aldehydes and 4-aryl-3-butyn-2-ones from arylacetylenes and amide acetals

The reaction of arylacetylenes 1 and N,N-dimethylformamide dimethylacetal (2a, DMF-DMA) afforded the corresponding arylpropargyl aldehydes 3 in moderate yields. Similarly, the reaction of 1 and N,N-dimethylacetamide dimethylacetal (2b, DMA-DMA) gave 4-aryl-3-butyn-2-ones 4.