405175-79-3

Basic information

• Product Name: (R)-4-N-CBZ-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER
• Synonyms: REF DUPL: (R)-4-N-Cbz-piperazine-2-carboxylic acid methyl ester;(R)-4-N-Cbz-piperazine-3-carboxylic acid methyl ester;(R)-4-N-CBZ-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER-HCl;(3R)-1,3-Piperazinedicarboxylic acid 3-methyl 1-(phenylmethyl) ester;Methyl (R)-4-N-Cbz-piperazine-3-carboxylate;1-benzyl 3-Methyl (3R)-piperazine-1,3-dicarboxylate
• CAS NO: 405175-79-3
• Molecular Formula: C₁₄H₁₈N₂O₄
• Molecular Weight: 278.306
• Mol File: 405175-79-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 406.5°C at 760 mmHg
• Flash Point: 199.7°C
• Appearance: /
• Density: 1.212
• Vapor Pressure: 8.08E-07mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-4-N-CBZ-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-N-CBZ-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER(405175-79-3)
• EPA Substance Registry System: (R)-4-N-CBZ-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER(405175-79-3)

Safety Data

• Hazardous Substances Data: 405175-79-3(Hazardous Substances Data)

Usage

General Description

(R)-4-N-CBZ-piperazine-2-carboxylic acid methyl ester is a chemical compound that is commonly used in organic synthesis and medicinal chemistry. It is an ester derivative of piperazine, an organic compound that is commonly used as a building block in the synthesis of pharmaceuticals and other bioactive molecules. This particular compound is important because of its chiral nature, as it contains a stereocenter, making it useful in the production of enantiomerically pure compounds. Due to its versatile nature, (R)-4-N-CBZ-piperazine-2-carboxylic acid methyl ester has found applications in the development of drugs, agrochemicals, and other fine chemicals. Its wide range of applications and importance in organic synthesis make it a valuable compound in chemistry and pharmaceutical research.

InChI:InChI=1/C14H18N2O4/c1-19-13(17)12-9-16(8-7-15-12)14(18)20-10-11-5-3-2-4-6-11/h2-6,12,15H,7-10H2,1H3/t12-/m1/s1

Upstream product

• 126330-92-5 3-amino-N-[(benzyloxy)carbonyl]-D-alanine methyl ester 
• 501-53-1 benzyl chloroformate 
• 126330-91-4 Methyl (R)-6-oxopiperazine-2-carboxylate 
• 129799-11-7 1-benzyl 3-methyl piperazine-1,3-dicarboxylate 
• 67-56-1 methanol 
• 138775-02-7 (2R)-4-[(benzyloxy)carbonyl]-1-[(tert-butoxy)carbonyl]piperazine-2-carboxylic acid 

Downstream Products

• 278790-00-4 piperazine-1,2,4-tricarboxylic acid 4-benzyl ester 1-tert-butyl ester 2-methyl ester 
• 405175-82-8 (R)-4-[Ethoxy-(4-methoxy-phenyl)-phosphinoyl]-piperazine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester 
• 954409-60-0 1-benzyl 3-methyl (3R)-4-{[1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}piperazine-1,3-dicarboxylate 
• 954410-00-5 methyl 3-[(3R)-4-{[1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-3-(hydroxymethyl)piperazin-1-yl]-1-naphthoate 
• 954409-59-7 ((2R)-1-{[1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}piperazin-2-yl)methyl acetate 
• 954409-61-1 benzyl (3R)-4-{[1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-3-(hydroxymethyl)-piperazine-1-carboxylate 
• 954409-62-2 benzyl (3R)-3-[(acetyloxy)methyl]-4-{[1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}piperazine-1-carboxylate 

Relevant articles and documents

Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors

There is an emerging global need for new and more effective antibiotics against multi-resistant bacteria. This situation has led to massive industrial investigations on novel bacterial topoisomerase inhibitors (NBTIs) that target the vital bacterial enzym

Expanded substrate scope and catalyst optimization for the catalytic kinetic resolution of N-heterocycles

The scope, reactivity, and selectivity of the chiral hydroxamic acid-catalyzed kinetic resolution of chiral amines are improved by a new catalyst structure and a more environmentally friendly reaction protocol. In addition to increasing selectivity across all substrates, these conditions make possible the resolution of N-heterocycles containing lactams or other basic functional groups that can inhibit the catalyst.