405264-04-2Relevant articles and documents
Preparation method of 2-fluoro-6-trifluoromethylbenzenesulfonylchloride
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Paragraph 0017; 0018; 0019, (2018/06/15)
The invention provides a preparation method of 2-fluoro-6-trifluoromethylbenzenesulfonylchloride. The method comprises the following steps: reacting fluoro-3-benzene and alkali serving as main raw materials in an organic solvent to generate a corresponding salt; reacting the generated salt with sulfuryl fluoride under a certain pressure to generate 2-fluoro-6-trifluoromethanesulphonyl fluoride; reacting filtered and distilled reaction liquid with calcium chloride in a mixed solution; filtering, separating and desolventizing the reaction liquid to obtain liquid-state 2-fluoro-6-trifluoromethylbenzenesulfonylchloride of which the yield is 85 percent or more and the purity is 96 percent or more. The preparation method of the 2-fluoro-6-trifluoromethylbenzenesulfonylchloride provided by the invention has the advantages of no use of highly-toxic or poisonous gas, mild conditions, easiness in controlling, adoption of readily-available raw materials, lower cost, no three waste (waste water, waste solid and waste gas) discharge, and suitability for industrial production.
2-fluoro-6-trifluoromethylbenzenesulfonyl chloride synthesis method
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, (2017/08/30)
The present invention provides a 2-fluoro-6-trifluoromethylbenzenesulfonyl chloride synthesis method. According to the reaction formula defined in the specification, o-trifluoromethylaniline is used as a raw material, and acylation, alkylation, nitration, dealkylation, reduction, diazotization fluorination, hydrolysis and sulfonylation are performed to synthesize an intermediate 2-fluoro-6-trifluoromethylbenzenesulfonyl chloride. According to the present invention, the target is that the synthesis process is suitable for the industrial production, the starting raw material is easy to obtain, the raw material cost is low, the process operating condition is mild, and the method is suitable for industrial production.
A 6 - substituted -2 - trifluoromethylbenzene sulfonyl chloride method for the preparation of
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Paragraph 0073; 0074; 0075; 0076; 0077, (2019/02/02)
The invention relates to a preparation method of 6-substituted-2-trifluoromethylbenzenesulfonyl chloride as a key intermediate of sulfonamide or sulfonylurea herbicides. The method comprises the following steps: 6-fluoro-2-trifluoromethylbenzenethioether is formed through fluorine displacement and sulfenyl group substitution of a raw material 2,3-dichlorobenzotrifluoride, chlorine oxidative chloridization or substitution of 6-fluoro-2-trifluoromethylbenzenethioether is carried out, and then chlorine oxidative chloridization of the finally obtained material is carried out to obtain the above product. The method has the advantages of easily available raw materials, simple process, high yield and low cost.