40575-42-6Relevant articles and documents
A simple method for the displacement of bromine by fluorine at tertiary benzylic or non-classical secondary sites
Leroux, Frédéric,Garamszegi, László,Schlosser, Manfred
, p. 177 - 180 (2002)
Iodine fluoride or, being its operational equivalent, the mixture of N-iodosuccinimide and triethylamine tris(hydrogen fluoride) reacts with tertiary and benzylic bromoalkanes to afford the respective fluoroalkanes in moderate-to-excellent yields. In contrast, primary bromoalkanes are virtually inert under identical conditions. Secondary bromoalkanes do not react either unless the heterolytically generated cationic intermediates benefit from non-classical resonance stabilization.
CREATINE PRODRUGS, COMPOSITIONS AND METHODS OF USE THEREOF
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Paragraph 00651; 00653, (2019/06/17)
The present disclosure provides creatine prodrug analogs and their compositions useful for the treatment of creatine deficiencies.
Efficient synthesis of α,β-unsaturated alkylimines performed with allyl cations and azides: Application to the synthesis of an ant venom alkaloid
Hayashi, Kyohei,Tanimoto, Hiroki,Zhang, Huan,Morimoto, Tsumoru,Nishiyama, Yasuhiro,Kakiuchi, Kiyomi
supporting information, p. 5728 - 5731 (2013/01/15)
An efficient synthesis of α,β-unsaturated alkylimines at low temperature using azides has been developed. Carbocations generated from allyl alcohols helped achieve a rapid conversion under mild conditions with azides to afford reactive α,β-unsaturated imines. Hydroxy or alkoxy groups are essential for these transformations, and utilizing readily accessible allyl alcohols gave a wide extension of substrates. The efficiency of this novel method is demonstrated in the total synthesis of an iminium ant venom alkaloid.