405939-39-1Relevant articles and documents
Halogen-Dance-Based Synthesis of Phosphonomethoxyethyl (PME) Substituted 2-Aminothiazoles as Potent Inhibitors of Bacterial Adenylate Cyclases
?esnek, Michal,?afránek, Michal,Dra?ínsky, Martin,Tlou??ová, Eva,Mertlíková-Kaiserová, Helena,Hayes, Michael P.,Watts, Val J.,Janeba, Zlatko
, (2021/10/25)
A series of acyclic nucleoside phosphonates (ANPs) was designed as inhibitors of bacterial adenylate cyclases (ACs), where adenine was replaced with 2-amino-4-arylthiazoles. The target compounds were prepared using the halogen dance reaction. Final AC inh
NOVEL INHIBITOR OF CYCLIN-DEPENDENT KINASE CDK9
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Paragraph 0059, (2020/03/13)
The present invention relates to an inhibitor of cyclin-dependent kinase CDK9, having a structure of formula (I). The present invention also provides a method of treating a cancer of a precancerous condition related to CDK9 activity with the inhibitor and a use of the same.
DIAZANAPHTHALEN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF
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Paragraph 0927-0928, (2019/05/15)
Diazanaphthalene compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a diazanaphthalene compound or analogs thereof, in the treatment of disorders characterized by the activa