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40600-13-3

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40600-13-3 Usage

Description

Cirazoline hydrochloride is an α1-adrenergic receptor (α1-AR) agonist that exhibits varying degrees of agonist activity at different α1-AR subtypes and acts as an antagonist at α2-ARs. It is characterized by its ability to activate α1-noradrenergic receptors and has been utilized in various studies to investigate the effects of different compounds on respiratory activity and behavior.

Uses

Used in Pharmaceutical Research:
Cirazoline hydrochloride is used as a research compound for studying the effects of α1-AR agonists on various physiological processes. It is particularly useful in understanding the role of these receptors in respiratory activity, as demonstrated by its use in the brainstem transverse slice study involving neurokinin1 (NK1) antagonists.
Used in Behavioral Studies:
Cirazoline hydrochloride is used as a behavioral modifier in animal models, specifically in mice, to enhance spatial memory and reduce depressiveand anxiety-like behaviors when administered at a concentration of 10 mg/L in drinking water for 2-9 months.
Used in Cognitive Performance Studies:
In aged rhesus monkeys, cirazoline hydrochloride is used as a cognitive enhancer at high doses of 1-10 μg/kg, improving performance in the variable delayed response task. However, it has been observed to impair performance at lower doses of 0.01-1 μg/kg.
Used in Cardiovascular Research:
Cirazoline hydrochloride is used as a pharmacological tool to investigate the effects of α1-AR agonists on blood pressure regulation. In anesthetized normotensive cats, microinjection of the compound into the nucleus reticularis lateralis (NRL) has been shown to decrease blood pressure, providing insights into the role of these receptors in cardiovascular function.

Biological Activity

Selective α 1 agonist. Also available as part of the α 1 -Adrenoceptor Tocriset? and Mixed Adrenergic Tocriset? .

Biochem/physiol Actions

Cirazoline is a selective α1-adrenoceptor agonist and also a non-selective ligand for the imidazoline binding site. Cirazoline dereases spatial working memory performance in aged monkeys.

Check Digit Verification of cas no

The CAS Registry Mumber 40600-13-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,6,0 and 0 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 40600-13:
(7*4)+(6*0)+(5*6)+(4*0)+(3*0)+(2*1)+(1*3)=63
63 % 10 = 3
So 40600-13-3 is a valid CAS Registry Number.
InChI:InChI=1/C13H16N2O.ClH/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13;/h1-4,10H,5-9H2,(H,14,15);1H

40600-13-3 Well-known Company Product Price

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  • Sigma

  • (C223)  Cirazoline hydrochloride  solid

  • 40600-13-3

  • C223-10MG

  • 1,282.32CNY

  • Detail

40600-13-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole,hydrochloride

1.2 Other means of identification

Product number -
Other names Cirazoline hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:40600-13-3 SDS

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